InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pea15a

Summary

InnateDB Gene

IDBG-205249.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pea15a

Gene Name

phosphoprotein enriched in astrocytes 15A

Synonyms

Mat1; PEA-15; Pea15; Pkcs15

Species

Mus musculus

Ensembl Gene

ENSMUSG00000013698

Encoded Proteins

IDBP-205251

phosphoprotein enriched in astrocytes 15A

IDBP-258541

phosphoprotein enriched in astrocytes 15A

IDBP-535862

phosphoprotein enriched in astrocytes 15A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162734:
This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. [provided by RefSeq, Sep 2011]
This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:172196728-172206804

Strand

Reverse strand

Band

Transcripts

ENSMUST00000013842	ENSMUSP00000013842
ENSMUST00000111247	ENSMUSP00000106878
ENSMUST00000125361
ENSMUST00000155109	ENSMUSP00000117735
ENSMUST00000152432

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0008643	carbohydrate transport
GO:0035556	intracellular signal transduction
GO:0042981	regulation of apoptotic process
GO:0043278	response to morphine
GO:0046325	negative regulation of glucose import
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005737	cytoplasm
GO:0005875	microtubule associated complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000162734

View Gene Order

ENSBTAG00000005793

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

p73pathway

p73 transcription factor network

Cross-References

SwissProt

Q62048

TrEMBL

D3Z375

UniProt Splice Variant

Entrez Gene

18611

UniGene

Mm.544

RefSeq

NM_011063 XM_006496702

OMIM

CCDS

CCDS15510

HPRD

IMGT

MGI ID

MGI:104799

MGI Symbol

Pea15a

EMBL

AC074310 AK089070 AK153141 AK153493 AK161635 AK161977 BC038282 X86694

GenPept

AAH38282 BAC40734 BAE31752 BAE32041 BAE36504 BAE36662 CAA60387

RNA Seq Atlas

18611