Version 5.4
Mus musculus Gene: Errfi1
Summary
InnateDB Gene IDBG-205853.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Errfi1
Gene Name ERBB receptor feedback inhibitor 1
Synonyms 1300002F13Rik; AI788755; Mig-6; Mig6; RALT
Species Mus musculus
Ensembl Gene ENSMUSG00000028967
Encoded Proteins
IDBP-205855
ERBB receptor feedback inhibitor 1
IDBP-205857
ERBB receptor feedback inhibitor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116285:
ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:150853919-150868892
Strand Forward strand
Band E2
Transcripts
ENSMUST00000073600 ENSMUSP00000073285
ENSMUST00000030811 ENSMUSP00000030811
ENSMUST00000128640
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
Biological Process
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0031953 negative regulation of protein autophosphorylation
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0043589 skin morphogenesis
GO:0045616 regulation of keratinocyte differentiation
GO:0048286 lung alveolus development
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0060426 lung vasculature development
GO:0060428 lung epithelium development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116285
View Gene Order
ENSBTAG00000006609
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q99JZ7
TrEMBL Q3TK48
UniProt Splice Variant
Entrez Gene 74155
UniGene Mm.318841 Mm.475529
RefSeq NM_133753 XM_006537088 XM_006539210
OMIM
CCDS CCDS18974
HPRD
IMGT
MGI ID MGI:1921405
MGI Symbol Errfi1
EMBL AK166791 AK167156 BC005546 BC057646 CH466594
GenPept AAH05546 AAH57646 BAE39021 BAE39297 EDL14895
RNA Seq Atlas 74155

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca