Version 5.4
Mus musculus Gene: Nlrp10
Summary
InnateDB Gene IDBG-205991.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nlrp10
Gene Name NLR family, pyrin domain containing 10
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000049709
Encoded Proteins
IDBP-205993
NLR family, pyrin domain containing 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 15096476
[Homo sapiens] NLRP10 oligomerizes and binds to PYCARD, inhibits PYCARD mediated NF-kappaB activation and apoptosis, as well as CASP1-mediated IL1B maturation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182261:
Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:108921860-108930158
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000055745 ENSMUSP00000050252
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0006952 defense response
GO:0008152 metabolic process
GO:0035397 helper T cell enhancement of adaptive immune response
GO:0036336 dendritic cell migration
GO:0045087 innate immune response
GO:0050829 defense response to Gram-negative bacterium
GO:0050832 defense response to fungus
GO:2000318 positive regulation of T-helper 17 type immune response
GO:2000484 positive regulation of interleukin-8 secretion
GO:2000778 positive regulation of interleukin-6 secretion
Cellular Component
GO:0005737 cytoplasm
GO:0019897 extrinsic component of plasma membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000182261
View Gene Order
Cross-References
SwissProt Q8CCN1
TrEMBL Q6JGS9
UniProt Splice Variant
Entrez Gene 244202
UniGene Mm.341480 Mm.37991 Mm.401861 Mm.403351
RefSeq NM_175532
OMIM
CCDS CCDS21730
HPRD
IMGT
MGI ID MGI:2444084
MGI Symbol Nlrp10
EMBL AK032446 AY355344 AY489193 BC113194 BC113801 CH466531
GenPept AAI13195 AAI13802 AAR14741 AAS67385 BAC27872 EDL16916
RNA Seq Atlas 244202

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca