Mus musculus Gene: Tub
Summary
InnateDB Gene IDBG-206024.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tub
Gene Name tubby candidate gene
Synonyms rd5; tub;
Species Mus musculus
Ensembl Gene ENSMUSG00000031028
Encoded Proteins
tubby candidate gene
tubby candidate gene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166402:
This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:109010825-109034460
Strand Forward strand
Band E3
Transcripts
ENSMUST00000033341 ENSMUSP00000033341
ENSMUST00000119474 ENSMUSP00000113580
ENSMUST00000147943
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008020 G-protein coupled photoreceptor activity
GO:0032403 protein complex binding
Biological Process
GO:0006909 phagocytosis
GO:0007602 phototransduction
GO:0007605 sensory perception of sound
GO:0009584 detection of visible light
GO:0009725 response to hormone
GO:0044259 multicellular organismal macromolecule metabolic process
GO:0050766 positive regulation of phagocytosis
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
G-protein signaling through tubby proteins [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.396787 Mm.439722
RefSeq NM_021885
OMIM
CCDS CCDS21732
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas