Version 5.4
Mus musculus Gene: Tgm3
Summary
InnateDB Gene IDBG-206095.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tgm3
Gene Name transglutaminase 3, E polypeptide
Synonyms AI893889; TG E; TG(E); TGase E; TGase-3; TGE
Species Mus musculus
Ensembl Gene ENSMUSG00000027401
Encoded Proteins
IDBP-260567
transglutaminase 3, E polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125780:
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:130012349-130050399
Strand Forward strand
Band F1
Transcripts
ENSMUST00000110299 ENSMUSP00000105928
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0003824 catalytic activity
GO:0003924 GTPase activity
GO:0005509 calcium ion binding
GO:0005525 GTP binding
GO:0019003 GDP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0008544 epidermis development
GO:0018149 peptide cross-linking
GO:0030216 keratinocyte differentiation
GO:0031424 keratinization
GO:0035315 hair cell differentiation
GO:0043163 cell envelope organization
GO:0043588 skin development
GO:0051262 protein tetramerization
Cellular Component
GO:0001533 cornified envelope
GO:0005737 cytoplasm
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000125780
View Gene Order
ENSBTAG00000001785
Not yet available
Cross-References
SwissProt Q08189
TrEMBL
UniProt Splice Variant
Entrez Gene 21818
UniGene Mm.2961
RefSeq NM_009374 XM_006499151
OMIM
CCDS CCDS38240
HPRD
IMGT
MGI ID MGI:98732
MGI Symbol Tgm3
EMBL AL808127 BC129890 BC129891 CH466519 L10385
GenPept AAA40421 AAI29891 AAI29892 CAM19029 EDL28248
RNA Seq Atlas 21818

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca