Mus musculus Gene: Ipo7
Summary
InnateDB Gene IDBG-206413.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ipo7
Gene Name importin 7
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000066232
Encoded Proteins
importin 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000205339:
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran\'s GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:110018425-110055114
Strand Forward strand
Band E3
Transcripts
ENSMUST00000084731 ENSMUSP00000081782
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008536 Ran GTPase binding
GO:0042393 histone binding
Biological Process
GO:0006606 protein import into nucleus
GO:0006886 intracellular protein transport
GO:0045087 innate immune response
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9EPL8
TrEMBL
UniProt Splice Variant
Entrez Gene 233726
UniGene
RefSeq NM_181517 XM_006507657
OMIM
CCDS CCDS40085
HPRD
IMGT
MGI ID MGI:2152414
MGI Symbol Ipo7
EMBL AJ278435 AK039534 AK053498 AY316153 BC053524 BC064825
GenPept AAH53524 AAH64825 AAP79888 BAC30376 BAC35405 CAC17143
RNA Seq Atlas 233726