Homo sapiens Gene: PALB2
Summary
InnateDB Gene IDBG-20644.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PALB2
Gene Name partner and localizer of BRCA2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000083093
Encoded Proteins
partner and localizer of BRCA2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:23603160-23641310
Strand Reverse strand
Band p12.2
Transcripts
ENST00000261584 ENSP00000261584
ENST00000568219 ENSP00000454703
ENST00000566069 ENSP00000459237
ENST00000567003
ENST00000561514 ENSP00000460666
ENST00000565038 ENSP00000459882
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0001756 somitogenesis
GO:0001833 inner cell mass cell proliferation
GO:0006281 DNA repair
GO:0007498 mesoderm development
GO:0009887 organ morphogenesis
GO:0036342 post-anal tail morphogenesis
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Fanconi Anemia pathway pathway
DNA Repair pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Fanconi anemia pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 79728
UniGene Hs.444664
RefSeq NM_024675
HUGO HGNC:26144
OMIM 610355
CCDS CCDS32406
HPRD 07966
IMGT
EMBL
GenPept
RNA Seq Atlas 79728