Version 5.4
Mus musculus Gene: Wee1
Summary
InnateDB Gene IDBG-206487.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wee1
Gene Name WEE 1 homolog 1 (S. pombe)
Synonyms Wee1A
Species Mus musculus
Ensembl Gene ENSMUSG00000031016
Encoded Proteins
IDBP-206489
WEE 1 homolog 1 (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166483:
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:110122350-110142112
Strand Forward strand
Band E3
Transcripts
ENSMUST00000033326 ENSMUSP00000033326
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0006468 protein phosphorylation
GO:0007067 mitotic nuclear division
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030010 establishment of cell polarity
GO:0048812 neuron projection morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166483
View Gene Order
ENSBTAG00000005278
Not yet available
Pathways
NETPATH
REACTOME
REACT_240530
G2/M Transition pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_224553
Hemostasis pathway
REACT_223647
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_251223
G2/M DNA damage checkpoint pathway
REACT_188804
Cell Cycle pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
REACT_235397
G2/M Checkpoints pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_206803
Cyclin A/B1 associated events during G2/M transition pathway
REACT_253002
G1/S Transition pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_245868
Cyclin E associated events during G1/S transition pathway
REACT_223573
G2/M DNA replication checkpoint pathway
REACT_239497
Polo-like kinase mediated events pathway
REACT_253623
S Phase pathway
REACT_236786
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex pathway
KEGG
mmu04110
Cell cycle pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1846
G2/M DNA replication checkpoint pathway
REACT_407
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex pathway
REACT_897
G2/M DNA damage checkpoint pathway
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_1006
Polo-like kinase mediated events pathway
REACT_1857
Cyclin A/B1 associated events during G2/M transition pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_828
G2/M Checkpoints pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_604
Hemostasis pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa04110
Cell cycle pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt P47810
TrEMBL
UniProt Splice Variant
Entrez Gene 22390
UniGene Mm.287173
RefSeq NM_009516
OMIM
CCDS CCDS21743
HPRD
IMGT
MGI ID MGI:103075
MGI Symbol Wee1
EMBL AJ278435 AK011212 BC006852 D30743
GenPept AAH06852 BAA06404 BAB27471 CAC17145
RNA Seq Atlas 22390

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca