Mus musculus Gene: Ccr2
Summary
InnateDB Gene IDBG-206567.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccr2
Gene Name chemokine (C-C motif) receptor 2
Synonyms Cc-ckr-2; Ccr2a; Ccr2b; Ckr2; Ckr2a; Ckr2b; Cmkbr2; mJe-r;
Species Mus musculus
Ensembl Gene ENSMUSG00000049103
Encoded Proteins
chemokine (C-C motif) receptor 2
chemokine (C-C motif) receptor 2
chemokine (C-C motif) receptor 2
chemokine (C-C motif) receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:124101950-124113557
Strand Forward strand
Band F4
Transcripts
ENSMUST00000055918 ENSMUSP00000049909
ENSMUST00000171719 ENSMUSP00000130112
ENSMUST00000168841 ENSMUSP00000132453
ENSMUST00000165984 ENSMUSP00000128734
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0016493 C-C chemokine receptor activity
GO:0019955 cytokine binding
GO:0035715 chemokine (C-C motif) ligand 2 binding
GO:0035716 chemokine (C-C motif) ligand 12 binding
GO:0035717 chemokine (C-C motif) ligand 7 binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001525 angiogenesis
GO:0001974 blood vessel remodeling
GO:0002246 wound healing involved in inflammatory response
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0002829 negative regulation of type 2 immune response
GO:0006874 cellular calcium ion homeostasis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006959 humoral immune response
GO:0006968 cellular defense response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0010574 regulation of vascular endothelial growth factor production
GO:0010820 positive regulation of T cell chemotaxis
GO:0016525 negative regulation of angiogenesis
GO:0019233 sensory perception of pain
GO:0019725 cellular homeostasis
GO:0030097 hemopoiesis
GO:0030334 regulation of cell migration
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0035705 T-helper 17 cell chemotaxis
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
GO:0043277 apoptotic cell clearance
GO:0043310 negative regulation of eosinophil degranulation
GO:0045627 positive regulation of T-helper 1 cell differentiation
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0050870 positive regulation of T cell activation
GO:0070098 chemokine-mediated signaling pathway
GO:0090026 positive regulation of monocyte chemotaxis
GO:0090265 positive regulation of immune complex clearance by monocytes and macrophages
GO:2000439 positive regulation of monocyte extravasation
GO:2000451 positive regulation of CD8-positive, alpha-beta T cell extravasation
GO:2000464 positive regulation of astrocyte chemotaxis
GO:2000473 positive regulation of hematopoietic stem cell migration
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0048471 perinuclear region of cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Defensins pathway
Beta defensins pathway
Innate Immune System pathway
GPCR downstream signaling pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
Immune System pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
G alpha (i) signalling events pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P51683
TrEMBL Q3TRK1 Q3U3U0 Q543S8
UniProt Splice Variant
Entrez Gene 12772
UniGene Mm.6272
RefSeq NM_009915 XM_006512428 XM_006512427 XM_006512426
OMIM
CCDS CCDS23669
HPRD
IMGT
MGI ID MGI:106185
MGI Symbol Ccr2
EMBL AK046579 AK138599 AK154590 AK162705 BC138803 BC138804 CH466671 U47035 U51717 U56819
GenPept AAC52453 AAC52557 AAC52784 AAI38804 AAI38805 BAC32793 BAE23710 BAE32695 BAE37028 EDL37176
RNA Seq Atlas 12772