InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ccr2

Summary

InnateDB Gene

IDBG-206567.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccr2

Gene Name

chemokine (C-C motif) receptor 2

Synonyms

Cc-ckr-2; Ccr2a; Ccr2b; Ckr2; Ckr2a; Ckr2b; Cmkbr2; mJe-r

Species

Mus musculus

Ensembl Gene

ENSMUSG00000049103

Encoded Proteins

IDBP-206569

chemokine (C-C motif) receptor 2

IDBP-622407

chemokine (C-C motif) receptor 2

IDBP-622410

chemokine (C-C motif) receptor 2

IDBP-622417

chemokine (C-C motif) receptor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:124101950-124113557

Strand

Forward strand

Band

Transcripts

ENSMUST00000055918	ENSMUSP00000049909
ENSMUST00000171719	ENSMUSP00000130112
ENSMUST00000168841	ENSMUSP00000132453
ENSMUST00000165984	ENSMUSP00000128734

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity
GO:0019955	cytokine binding
GO:0035715	chemokine (C-C motif) ligand 2 binding
GO:0035716	chemokine (C-C motif) ligand 12 binding
GO:0035717	chemokine (C-C motif) ligand 7 binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001525	angiogenesis
GO:0001974	blood vessel remodeling
GO:0002246	wound healing involved in inflammatory response
GO:0002827	positive regulation of T-helper 1 type immune response
GO:0002829	negative regulation of type 2 immune response
GO:0006874	cellular calcium ion homeostasis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0006959	humoral immune response
GO:0006968	cellular defense response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010574	regulation of vascular endothelial growth factor production
GO:0010820	positive regulation of T cell chemotaxis
GO:0016525	negative regulation of angiogenesis
GO:0019233	sensory perception of pain
GO:0019725	cellular homeostasis
GO:0030097	hemopoiesis
GO:0030334	regulation of cell migration
GO:0032729	positive regulation of interferon-gamma production
GO:0032743	positive regulation of interleukin-2 production
GO:0035705	T-helper 17 cell chemotaxis
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0043277	apoptotic cell clearance
GO:0043310	negative regulation of eosinophil degranulation
GO:0045627	positive regulation of T-helper 1 cell differentiation
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0050729	positive regulation of inflammatory response
GO:0050870	positive regulation of T cell activation
GO:0070098	chemokine-mediated signaling pathway
GO:0090026	positive regulation of monocyte chemotaxis
GO:0090265	positive regulation of immune complex clearance by monocytes and macrophages
GO:2000439	positive regulation of monocyte extravasation
GO:2000451	positive regulation of CD8-positive, alpha-beta T cell extravasation
GO:2000464	positive regulation of astrocyte chemotaxis
GO:2000473	positive regulation of hematopoietic stem cell migration

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:0048471	perinuclear region of cytoplasm