Mus musculus Gene: Eif4g2
Summary
InnateDB Gene IDBG-206810.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif4g2
Gene Name eukaryotic translation initiation factor 4, gamma 2
Synonyms AA589388; DAP-5; E130105L11Rik; Nat1; Natm1; p97;
Species Mus musculus
Ensembl Gene ENSMUSG00000005610
Encoded Proteins
eukaryotic translation initiation factor 4, gamma 2
eukaryotic translation initiation factor 4, gamma 2
eukaryotic translation initiation factor 4, gamma 2
eukaryotic translation initiation factor 4, gamma 2
eukaryotic translation initiation factor 4, gamma 2
eukaryotic translation initiation factor 4, gamma 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G, that contains the binding sites for eIF4A and eIF3; eIF4G in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA, which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:111070568-111083030
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000162415 ENSMUSP00000124551
ENSMUST00000161051 ENSMUSP00000125375
ENSMUST00000161079
ENSMUST00000161158
ENSMUST00000163014 ENSMUSP00000123811
ENSMUST00000159465
ENSMUST00000160552
ENSMUST00000161790
ENSMUST00000161736
ENSMUST00000161682
ENSMUST00000160132 ENSMUSP00000124914
ENSMUST00000159305 ENSMUSP00000125098
ENSMUST00000162394
ENSMUST00000160966 ENSMUSP00000125301
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006413 translational initiation
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
RNA transport pathway
Viral myocarditis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
ISG15 antiviral mechanism pathway
KEGG
RNA transport pathway
Viral myocarditis pathway
INOH
PID BIOCARTA
Internal ribosome entry pathway [Biocarta view]
Eukaryotic protein translation [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 13690
UniGene Mm.381030 Mm.408376 Mm.472532
RefSeq NM_013507 NM_001040131
OMIM
CCDS CCDS40088 CCDS40087
HPRD
IMGT
MGI ID MGI:109207
MGI Symbol Eif4g2
EMBL
GenPept
RNA Seq Atlas 13690