InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mad1l1

Summary

InnateDB Gene

IDBG-206816.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mad1l1

Gene Name

MAD1 mitotic arrest deficient 1-like 1

Synonyms

AI173502; AW550425; Mad1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029554

Encoded Proteins

IDBP-206818

mitotic arrest deficient 1-like 1

IDBP-259416

mitotic arrest deficient 1-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000002822:
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:140008689-140321552

Strand

Reverse strand

Band

Transcripts

ENSMUST00000031534	ENSMUSP00000031534
ENSMUST00000110829	ENSMUSP00000106453
ENSMUST00000128579
ENSMUST00000129747
ENSMUST00000132832

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	7 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007067	mitotic nuclear division
GO:0007094	mitotic spindle assembly checkpoint
GO:0090235	regulation of metaphase plate congression

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005815	microtubule organizing center
GO:0015629	actin cytoskeleton
GO:0072686	mitotic spindle