InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nudt1

Summary

InnateDB Gene

IDBG-206856.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nudt1

Gene Name

nudix (nucleoside diphosphate linked moiety X)-type motif 1

Synonyms

Mth1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036639

Encoded Proteins

IDBP-206858

nudix (nucleoside diphosphate linked moiety X)-type motif 1

IDBP-206860

nudix (nucleoside diphosphate linked moiety X)-type motif 1

IDBP-259420

nudix (nucleoside diphosphate linked moiety X)-type motif 1

IDBP-259422

nudix (nucleoside diphosphate linked moiety X)-type motif 1

IDBP-259424

nudix (nucleoside diphosphate linked moiety X)-type motif 1

IDBP-534557

nudix (nucleoside diphosphate linked moiety X)-type motif 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106268:
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:140331860-140338137

Strand

Forward strand

Band

Transcripts

ENSMUST00000071881	ENSMUSP00000071778
ENSMUST00000050205	ENSMUSP00000059983
ENSMUST00000110827	ENSMUSP00000106451
ENSMUST00000110826	ENSMUSP00000106450
ENSMUST00000110825	ENSMUSP00000106449
ENSMUST00000145898	ENSMUSP00000120347

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO:0016787	hydrolase activity
GO:0030515	snoRNA binding
GO:0035539	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
GO:0046872	metal ion binding
GO:0047693	ATP diphosphatase activity

Biological Process

GO:0006184	GTP catabolic process
GO:0006195	purine nucleotide catabolic process
GO:0006200	ATP catabolic process
GO:0006203	dGTP catabolic process
GO:0006281	DNA repair
GO:0042262	DNA protection
GO:0046061	dATP catabolic process

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0031965	nuclear membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000106268

View Gene Order

ENSBTAG00000002480

Not yet available

Pathways

NETPATH

REACTOME

REACT_188937

Metabolism pathway

REACT_196618

Phosphate bond hydrolysis by NUDT proteins pathway

REACT_245662

Metabolism of nucleotides pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

D3YWH7

UniProt Splice Variant

Entrez Gene

17766

UniGene

Mm.118846

RefSeq

NM_008637 XM_006504655 XM_006504656

OMIM

CCDS

CCDS19818

HPRD

IMGT

MGI ID

MGI:109280

MGI Symbol

Nudt1

EMBL

AC131670

GenPept

RNA Seq Atlas

17766