Homo sapiens Gene: ESM1
Summary
InnateDB Gene IDBG-20693.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ESM1
Gene Name endothelial cell-specific molecule 1
Synonyms endocan;
Species Homo sapiens
Ensembl Gene ENSG00000164283
Encoded Proteins
endothelial cell-specific molecule 1
endothelial cell-specific molecule 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:54977864-55022671
Strand Reverse strand
Band q11.2
Transcripts
ENST00000381405 ENSP00000370812
ENST00000381403 ENSP00000370810
ENST00000598310
ENST00000601836 ENSP00000471642
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005171 hepatocyte growth factor receptor binding
GO:0005178 integrin binding
GO:0005520 insulin-like growth factor binding
Biological Process
GO:0001525 angiogenesis
GO:0001558 regulation of cell growth
GO:0002040 sprouting angiogenesis
GO:0008284 positive regulation of cell proliferation
GO:1902204 positive regulation of hepatocyte growth factor receptor signaling pathway
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL M0R154
UniProt Splice Variant
Entrez Gene 11082
UniGene Hs.129944 Hs.619476
RefSeq NM_007036 NM_001135604
HUGO HGNC:3466
OMIM 601521
CCDS CCDS3963 CCDS47206
HPRD 03310
IMGT
EMBL AC010436 AC034238
GenPept
RNA Seq Atlas 11082