Version 5.4
Homo sapiens Gene: ESM1
Summary
InnateDB Gene IDBG-20693.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ESM1
Gene Name endothelial cell-specific molecule 1
Synonyms endocan
Species Homo sapiens
Ensembl Gene ENSG00000164283
Encoded Proteins
IDBP-20695
endothelial cell-specific molecule 1
IDBP-20699
endothelial cell-specific molecule 1
IDBP-717361
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:54977864-55022671
Strand Reverse strand
Band q11.2
Transcripts
ENST00000381405 ENSP00000370812
ENST00000381403 ENSP00000370810
ENST00000598310
ENST00000601836 ENSP00000471642
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005171 hepatocyte growth factor receptor binding
GO:0005178 integrin binding
GO:0005520 insulin-like growth factor binding
Biological Process
GO:0001525 angiogenesis
GO:0001558 regulation of cell growth
GO:0002040 sprouting angiogenesis
GO:0008284 positive regulation of cell proliferation
GO:1902204 positive regulation of hepatocyte growth factor receptor signaling pathway
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042379
View Gene Order
ENSBTAG00000004221
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.129944 Hs.619476
RefSeq NM_001135604 NM_007036
HUGO
OMIM
CCDS CCDS3963 CCDS47206
HPRD 03310
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca