Version 5.4
Mus musculus Gene: Pycr2
Summary
InnateDB Gene IDBG-207357.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pycr2
Gene Name pyrroline-5-carboxylate reductase family, member 2
Synonyms 1810018M05Rik; P5cr2
Species Mus musculus
Ensembl Gene ENSMUSG00000026520
Encoded Proteins
IDBP-207359
pyrroline-5-carboxylate reductase family, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143811:
This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:180904274-180908087
Strand Forward strand
Band H4
Transcripts
ENSMUST00000027802 ENSMUSP00000027802
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004735 pyrroline-5-carboxylate reductase activity
Biological Process
GO:0006561 proline biosynthetic process
GO:0055114 oxidation-reduction process
GO:0055129 L-proline biosynthetic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143811
View Gene Order
ENSBTAG00000005835
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00330
Arginine and proline metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00330
Arginine and proline metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q922Q4
TrEMBL Q3TMZ1
UniProt Splice Variant
Entrez Gene 69051
UniGene
RefSeq NM_133705
OMIM
CCDS CCDS15576
HPRD
IMGT
MGI ID MGI:1277956
MGI Symbol Pycr2
EMBL AK165618 BC006882 CH466555
GenPept AAH06882 BAE38298 EDL13142
RNA Seq Atlas 69051

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca