Homo sapiens Gene: PLK1
Summary
InnateDB Gene IDBG-20740.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLK1
Gene Name polo-like kinase 1
Synonyms PLK; STPK13;
Species Homo sapiens
Ensembl Gene ENSG00000166851
Encoded Proteins
polo-like kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PLK1 is a IKKgamma/NEMO-binding domain (gammaBD) kinase, which negatively regulates TNF-induced IKK activation and cyclin D1 expression.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:23677656-23690367
Strand Forward strand
Band p12.2
Transcripts
ENST00000300093 ENSP00000300093
ENST00000567897 ENSP00000459688
ENST00000568568 ENSP00000460084
ENST00000562272
ENST00000564947
ENST00000562407
ENST00000564202
ENST00000564794
ENST00000570220 ENSP00000460266
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 261 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 261 [view]
Protein-Protein 251 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 8 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0010997 anaphase-promoting complex binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000278 mitotic cell cycle
GO:0000281 mitotic cytokinesis
GO:0000910 cytokinesis
GO:0001578 microtubule bundle formation
GO:0006468 protein phosphorylation
GO:0007067 mitotic nuclear division
GO:0007077 mitotic nuclear envelope disassembly
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0007092 activation of mitotic anaphase-promoting complex activity
GO:0007094 mitotic spindle assembly checkpoint
GO:0007346 regulation of mitotic cell cycle
GO:0008283 cell proliferation
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0016567 protein ubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0030071 regulation of mitotic metaphase/anaphase transition
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031572 G2 DNA damage checkpoint
GO:0031648 protein destabilization
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0040038 polar body extrusion after meiotic divisions
GO:0043066 negative regulation of apoptotic process
GO:0043393 regulation of protein binding
GO:0045087 innate immune response (InnateDB)
GO:0045184 establishment of protein localization
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045862 positive regulation of proteolysis
GO:0046677 response to antibiotic
GO:0051297 centrosome organization
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0051726 regulation of cell cycle
GO:0071168 protein localization to chromatin
Cellular Component
GO:0000776 kinetochore
GO:0000922 spindle pole
GO:0000942 condensed nuclear chromosome outer kinetochore
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0015630 microtubule cytoskeleton
GO:0030496 midbody
GO:0051233 spindle midzone
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cyclin A/B1 associated events during G2/M transition pathway
Mitotic Telophase/Cytokinesis pathway
Phosphorylation of Emi1 pathway
APC/C-mediated degradation of cell cycle proteins pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Condensation of Prophase Chromosomes pathway
Regulation of mitotic cell cycle pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Loss of Nlp from mitotic centrosomes pathway
Recruitment of mitotic centrosome proteins and complexes pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Separation of Sister Chromatids pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
Golgi Cisternae Pericentriolar Stack Reorganization pathway
M Phase pathway
Mitotic Anaphase pathway
Centrosome maturation pathway
G2/M Transition pathway
Mitotic Prophase pathway
Activation of NIMA Kinases NEK9, NEK6, NEK7 pathway
Cell Cycle, Mitotic pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Mitotic G2-G2/M phases pathway
Polo-like kinase mediated events pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Metaphase/Anaphase Transition pathway
Phosphorylation of the APC/C pathway
Nuclear Envelope Breakdown pathway
Mitotic Metaphase and Anaphase pathway
KEGG
Cell cycle pathway
Oocyte meiosis pathway
Progesterone-mediated oocyte maturation pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
Polo-like kinase signaling events in the cell cycle
FoxO family signaling
p73 transcription factor network
ATR signaling pathway
Validated transcriptional targets of TAp63 isoforms
FOXM1 transcription factor network
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592049
RefSeq NM_005030
HUGO
OMIM
CCDS CCDS10616
HPRD 03652
IMGT
EMBL
GenPept
RNA Seq Atlas