InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pak7

Summary

InnateDB Gene

IDBG-207779.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pak7

Gene Name

p21 protein (Cdc42/Rac)-activated kinase 7

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039913

Encoded Proteins

IDBP-207781

p21 protein (Cdc42/Rac)-activated kinase 7

IDBP-207783

p21 protein (Cdc42/Rac)-activated kinase 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101349:
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:136081104-136387967

Strand

Reverse strand

Band

Transcripts

ENSMUST00000077200	ENSMUSP00000076440
ENSMUST00000035264	ENSMUSP00000047285
ENSMUST00000143329

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007010	cytoskeleton organization
GO:0007612	learning
GO:0007613	memory
GO:0007626	locomotory behavior
GO:0016049	cell growth
GO:0023014	signal transduction by phosphorylation
GO:0035556	intracellular signal transduction
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway