Version 5.4
Mus musculus Gene: Akap1
Summary
InnateDB Gene IDBG-208001.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akap1
Gene Name A kinase (PRKA) anchor protein 1
Synonyms Akap; AKAP121; AKAP84; C76494; C81186; DAKAP1; S-AKAP84
Species Mus musculus
Ensembl Gene ENSMUSG00000018428
Encoded Proteins
IDBP-208003
A kinase (PRKA) anchor protein 1
IDBP-265677
A kinase (PRKA) anchor protein 1
IDBP-265679
A kinase (PRKA) anchor protein 1
IDBP-536551
A kinase (PRKA) anchor protein 1
IDBP-539329
A kinase (PRKA) anchor protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121057:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:88830792-88864586
Strand Reverse strand
Band C
Transcripts
ENSMUST00000018572 ENSMUSP00000018572
ENSMUST00000107904 ENSMUSP00000103537
ENSMUST00000107903 ENSMUSP00000103536
ENSMUST00000143720 ENSMUSP00000122295
ENSMUST00000153961
ENSMUST00000153787 ENSMUSP00000123018
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 15 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000121057
View Gene Order
ENSBTAG00000025320
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
Cross-References
SwissProt O08715
TrEMBL
UniProt Splice Variant
Entrez Gene 11640
UniGene Mm.2969 Mm.465395
RefSeq NM_001042541 NM_009648
OMIM
CCDS CCDS25229
HPRD
IMGT
MGI ID MGI:104729
MGI Symbol Akap1
EMBL AL596180 U84389 U95145 U95146
GenPept AAB53740 AAB53741 AAC27100 CAI24699
RNA Seq Atlas 11640

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca