Version 5.4
Mus musculus Gene: Arpc1b
Summary
InnateDB Gene IDBG-208513.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arpc1b
Gene Name actin related protein 2/3 complex, subunit 1B
Synonyms 41kDa; AA408064; AA408534; AA571392; AF007010; AW208418; L72; p41-ARC; SOP2Hs
Species Mus musculus
Ensembl Gene ENSMUSG00000029622
Encoded Proteins
IDBP-208515
actin related protein 2/3 complex, subunit 1B
IDBP-536091
actin related protein 2/3 complex, subunit 1B
IDBP-539597
actin related protein 2/3 complex, subunit 1B
IDBP-535111
actin related protein 2/3 complex, subunit 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130429:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:145114215-145130705
Strand Forward strand
Band G2
Transcripts
ENSMUST00000085679 ENSMUSP00000082822
ENSMUST00000129033
ENSMUST00000126343
ENSMUST00000141602 ENSMUSP00000122340
ENSMUST00000136074 ENSMUSP00000115022
ENSMUST00000138900
ENSMUST00000138235
ENSMUST00000128229
ENSMUST00000138922 ENSMUSP00000115515
ENSMUST00000144375
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0030833 regulation of actin filament polymerization
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000130429
View Gene Order
ENSBTAG00000046248
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04810
Regulation of actin cytoskeleton pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
INOH
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
rac1_pathway
RAC1 signaling pathway
cdc42_pathway
CDC42 signaling events
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.30010 Mm.470460
RefSeq NM_023142 XM_006544567 XM_486686
OMIM
CCDS CCDS19856
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca