InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Flt1

Summary

InnateDB Gene

IDBG-209098.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Flt1

Gene Name

FMS-like tyrosine kinase 1

Synonyms

AI323757; Flt-1; sFlt1; VEGFR-1; VEGFR1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029648

Encoded Proteins

IDBP-209100

FMS-like tyrosine kinase 1

IDBP-209102

FMS-like tyrosine kinase 1

IDBP-260069

FMS-like tyrosine kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102755:
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:147561604-147726011

Strand

Reverse strand

Band

Transcripts

ENSMUST00000031653	ENSMUSP00000031653
ENSMUST00000031652	ENSMUSP00000031652
ENSMUST00000110529	ENSMUSP00000106158
ENSMUST00000125272
ENSMUST00000142477

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005021	vascular endothelial growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0036326	VEGF-A-activated receptor activity
GO:0036327	VEGF-B-activated receptor activity
GO:0036332	placental growth factor-activated receptor activity
GO:0042802	identical protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001569	patterning of blood vessels
GO:0002040	sprouting angiogenesis
GO:0002548	monocyte chemotaxis
GO:0006468	protein phosphorylation
GO:0010863	positive regulation of phospholipase C activity
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030154	cell differentiation
GO:0030335	positive regulation of cell migration
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0036323	vascular endothelial growth factor receptor-1 signaling pathway
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0043406	positive regulation of MAP kinase activity
GO:0043410	positive regulation of MAPK cascade
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045766	positive regulation of angiogenesis
GO:0046777	protein autophosphorylation
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048514	blood vessel morphogenesis
GO:0048598	embryonic morphogenesis