Mus musculus Gene: Hmgb1 | |||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-209311.6 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | Hmgb1 | ||||||||||||||||||||||||||
Gene Name | high mobility group box 1 | ||||||||||||||||||||||||||
Synonyms | amphoterin; DEF; HMG-1; Hmg1; p30; SBP-1 | ||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000066551 | ||||||||||||||||||||||||||
Encoded Proteins |
high mobility group box 1
high mobility group box 1
high mobility group box 1
high mobility group box 1
high mobility group box 1
|
||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||
Summary |
Hmgb1 is an endogenous Tlr4 ligand in macrophages and its release in wounds initiates Tlr4-dependent responses that contribute to neovascularization.
Hmgb1 plays a key regulatory role in polymorphonuclear neutrophil (PMN) recruitment to inflammatory tissues. Low concentrations of Hmgb1 (50-100 ng/ml) reduce baseline PMN migration as well as formyl-methionyl-leucyl-phenylalanine- and Il8-induced PMN chemotaxis, whereas higher Hmgb1 concentrations (5000 ng/ml) have a chemoattractant effect on PMN through Il8 production . (Demonstrated in human)
Hmgb1 has a pathogenic role in arthritis, where in complex with lipopolysaccharide, Il1a or Il1b, Hmgb1 boosts the production of proinflammatory cytokines and Mmp3 as demonstrated in synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients. (Demonstrated in human)
Nuclear Hmgb1 translocates to the cytoplasm in LPS-stimulated macrophages to potentiate inflammatory responses. (Demonstrated in mice)
|
||||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||
Summary |
[Homo sapiens] HMGB1 functions as universal sentinel for nucleic-acid-mediated innate immune responses.
[Homo sapiens] HMGB1 activates innate immunity mechanisms as a complex with DNA, lipids and/or pro-inflammatory cytokines.
[Homo sapiens] HMGB1 is an alarmin and a key mediator of natural killer (NK)-dendritic cell (DC) cross-talk and plays a pivotal role in the escape of Human Immunodeficiency Virus (HIV)-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk by upregulating c-FLIP and c-IAP2 expression.
[Homo sapiens] HMGB1 is an endogenous TLR4 ligand in macrophages and its release in wounds initiates TLR4-dependent responses that contribute to neovascularization. (Demonstrated in murine model)
[Homo sapiens] HMGB1 is found in high concentrations within neutrophil extracellular traps (NETs). HMGB1 is a neutrophil protein that facilitates the uptake and recognition of mammalian DNA by plasmacytoid dendritic cells, and may play a role in Systemic Lupus Erthermatosus autoimmunity.
[Homo sapiens] HMGB1 plays a key regulatory role in polymorphonuclear neutrophil (PMN) recruitment to inflammatory tissues. Low concentrations of HMGB1 (50-100 ng/ml) reduce baseline PMN migration as well as formyl-methionyl-leucyl-phenylalanine- and IL8-induced PMN chemotaxis, whereas higher HMGB1 concentrations (5000 ng/ml) have a chemoattractant effect on PMN through IL8 production.
[Homo sapiens] HMGB1 has a pathogenic role in arthritis, where in complex with lipopolysaccharide, IL1A or IL1B, HMGB1 boosts the production of proinflammatory cytokines and MMP3 as demonstrated in synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients.
[Homo sapiens] Nuclear HMGB1 translocates to the cytoplasm in LPS-stimulated macrophages to potentiate inflammatory responses. (Demonstrated in mice)
[Homo sapiens] Mast cell chymase CMA1 contributes to the control of inflammation by degrading the virulence factor Hsp70 of Trichinella spiralis, as well as several alarmins such as endogenous HSPA1A, BGN, and HMGB1..
|
||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000189403:
|
||||||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome 5:149046702-149053513 | ||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||
Band | G3 | ||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.
|
||||||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||||||
Pathways | |||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||
REACTOME |
TRAF6 mediated NF-kB activation pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Apoptosis pathway
Apoptosis induced DNA fragmentation pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Activation of DNA fragmentation factor pathway
Advanced glycosylation endproduct receptor signaling pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
Toll-Like Receptors Cascades pathway
MyD88 dependent cascade initiated on endosome pathway
Cytosolic sensors of pathogen-associated DNA pathway
RIP-mediated NFkB activation via ZBP1 pathway
Activated TLR4 signalling pathway
MyD88-independent cascade pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Apoptotic execution phase pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
|
||||||||||||||||||||||||||
KEGG |
Base excision repair pathway
|
||||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
NETPATH |
TNFalpha pathway
|
||||||||||||||||||||||||||
REACTOME |
RIP-mediated NFkB activation via ZBP1 pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
TRAF6 mediated NF-kB activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Advanced glycosylation endproduct receptor signaling pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Activation of DNA fragmentation factor pathway
Apoptotic execution phase pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Apoptosis induced DNA fragmentation pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Apoptosis pathway
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
Immune System pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Cytosolic sensors of pathogen-associated DNA pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Apoptosis induced DNA fragmentation pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Activated TLR4 signalling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88-independent cascade pathway
Cytosolic sensors of pathogen-associated DNA pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
Immune System pathway
Activation of DNA fragmentation factor pathway
Toll-Like Receptors Cascades pathway
TRAF6 mediated NF-kB activation pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Advanced glycosylation endproduct receptor signaling pathway
Apoptotic execution phase pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MyD88 dependent cascade initiated on endosome pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Innate Immune System pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
RIP-mediated NFkB activation via ZBP1 pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Apoptosis pathway
MyD88 cascade initiated on plasma membrane pathway
|
||||||||||||||||||||||||||
KEGG |
Base excision repair pathway
|
||||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||||
PID NCI |
Beta3 integrin cell surface interactions
amb2 Integrin signaling
Endogenous TLR signaling
|
||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | P63158 | ||||||||||||||||||||||||||
TrEMBL | D3YVC6 D3YZ18 Q58EV5 Q8BNM0 Q8C7C4 | ||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 619937 | ||||||||||||||||||||||||||
UniGene | Mm.207047 Mm.402118 Mm.437213 Mm.455366 Mm.461535 Mm.470617 | ||||||||||||||||||||||||||
RefSeq | NM_010439 XM_003945339 XM_006517801 XM_006543113 XM_006544655 | ||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||
CCDS | CCDS19883 | ||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
MGI ID | MGI:96113 | ||||||||||||||||||||||||||
MGI Symbol | Hmgb1 | ||||||||||||||||||||||||||
EMBL | AC158782 AK037928 AK050659 AK082902 AK084841 AK157846 BC006586 BC008565 BC083067 BC085090 BC091741 BC094030 BC110667 BC111468 L38477 U00431 X80457 Z11997 | ||||||||||||||||||||||||||
GenPept | AAA20508 AAA57042 AAH06586 AAH08565 AAH83067 AAH85090 AAH91741 AAH94030 AAI10668 AAI11469 BAC29902 BAC34367 BAC38678 BAC39289 BAE34226 CAA56631 CAA78042 | ||||||||||||||||||||||||||
RNA Seq Atlas | 100862258 102642363 15289 619937 | ||||||||||||||||||||||||||