Mus musculus Gene: Hmgb1
Summary
InnateDB Gene IDBG-209311.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hmgb1
Gene Name high mobility group box 1
Synonyms amphoterin; DEF; HMG-1; Hmg1; p30; SBP-1;
Species Mus musculus
Ensembl Gene ENSMUSG00000066551
Encoded Proteins
high mobility group box 1
high mobility group box 1
high mobility group box 1
high mobility group box 1
high mobility group box 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Hmgb1 is an endogenous Tlr4 ligand in macrophages and its release in wounds initiates Tlr4-dependent responses that contribute to neovascularization.
Hmgb1 plays a key regulatory role in polymorphonuclear neutrophil (PMN) recruitment to inflammatory tissues. Low concentrations of Hmgb1 (50-100 ng/ml) reduce baseline PMN migration as well as formyl-methionyl-leucyl-phenylalanine- and Il8-induced PMN chemotaxis, whereas higher Hmgb1 concentrations (5000 ng/ml) have a chemoattractant effect on PMN through Il8 production . (Demonstrated in human)
Hmgb1 has a pathogenic role in arthritis, where in complex with lipopolysaccharide, Il1a or Il1b, Hmgb1 boosts the production of proinflammatory cytokines and Mmp3 as demonstrated in synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients. (Demonstrated in human)
Nuclear Hmgb1 translocates to the cytoplasm in LPS-stimulated macrophages to potentiate inflammatory responses. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] HMGB1 functions as universal sentinel for nucleic-acid-mediated innate immune responses.
[Homo sapiens] HMGB1 activates innate immunity mechanisms as a complex with DNA, lipids and/or pro-inflammatory cytokines.
[Homo sapiens] HMGB1 is an alarmin and a key mediator of natural killer (NK)-dendritic cell (DC) cross-talk and plays a pivotal role in the escape of Human Immunodeficiency Virus (HIV)-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk by upregulating c-FLIP and c-IAP2 expression.
[Homo sapiens] HMGB1 is an endogenous TLR4 ligand in macrophages and its release in wounds initiates TLR4-dependent responses that contribute to neovascularization. (Demonstrated in murine model)
[Homo sapiens] HMGB1 is found in high concentrations within neutrophil extracellular traps (NETs). HMGB1 is a neutrophil protein that facilitates the uptake and recognition of mammalian DNA by plasmacytoid dendritic cells, and may play a role in Systemic Lupus Erthermatosus autoimmunity.
[Homo sapiens] HMGB1 plays a key regulatory role in polymorphonuclear neutrophil (PMN) recruitment to inflammatory tissues. Low concentrations of HMGB1 (50-100 ng/ml) reduce baseline PMN migration as well as formyl-methionyl-leucyl-phenylalanine- and IL8-induced PMN chemotaxis, whereas higher HMGB1 concentrations (5000 ng/ml) have a chemoattractant effect on PMN through IL8 production.
[Homo sapiens] HMGB1 has a pathogenic role in arthritis, where in complex with lipopolysaccharide, IL1A or IL1B, HMGB1 boosts the production of proinflammatory cytokines and MMP3 as demonstrated in synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients.
[Homo sapiens] Nuclear HMGB1 translocates to the cytoplasm in LPS-stimulated macrophages to potentiate inflammatory responses. (Demonstrated in mice)
[Homo sapiens] Mast cell chymase CMA1 contributes to the control of inflammation by degrading the virulence factor Hsp70 of Trichinella spiralis, as well as several alarmins such as endogenous HSPA1A, BGN, and HMGB1..
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000189403:
Gene Information
Type Protein coding
Genomic Location Chromosome 5:149046702-149053513
Strand Reverse strand
Band G3
Transcripts
ENSMUST00000085546 ENSMUSP00000082682
ENSMUST00000093196 ENSMUSP00000106131
ENSMUST00000110505 ENSMUSP00000106132
ENSMUST00000155086
ENSMUST00000139443
ENSMUST00000138553 ENSMUSP00000118733
ENSMUST00000133667
ENSMUST00000125605 ENSMUSP00000114515
ENSMUST00000123645
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 41 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 62 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001786 phosphatidylserine binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008201 heparin binding
GO:0044822 poly(A) RNA binding
GO:0070491 repressing transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002437 inflammatory response to antigenic stimulus
GO:0006288 base-excision repair, DNA ligation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006954 inflammatory response
GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0033151 V(D)J recombination
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043388 positive regulation of DNA binding
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:2000426 negative regulation of apoptotic cell clearance
Cellular Component
GO:0000793 condensed chromosome
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0017053 transcriptional repressor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
TRAF6 mediated NF-kB activation pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Apoptosis pathway
Apoptosis induced DNA fragmentation pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Activation of DNA fragmentation factor pathway
Advanced glycosylation endproduct receptor signaling pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
Toll-Like Receptors Cascades pathway
MyD88 dependent cascade initiated on endosome pathway
Cytosolic sensors of pathogen-associated DNA pathway
RIP-mediated NFkB activation via ZBP1 pathway
Activated TLR4 signalling pathway
MyD88-independent cascade pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Apoptotic execution phase pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
Base excision repair pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
Apoptotic execution phase pathway
RIP-mediated NFkB activation via ZBP1 pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Apoptosis induced DNA fragmentation pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
MyD88 cascade initiated on plasma membrane pathway
Innate Immune System pathway
Activation of DNA fragmentation factor pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
TRAF6 mediated NF-kB activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Apoptosis pathway
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
Advanced glycosylation endproduct receptor signaling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Cytosolic sensors of pathogen-associated DNA pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Apoptosis induced DNA fragmentation pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Activated TLR4 signalling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88-independent cascade pathway
Cytosolic sensors of pathogen-associated DNA pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
Immune System pathway
Activation of DNA fragmentation factor pathway
Toll-Like Receptors Cascades pathway
TRAF6 mediated NF-kB activation pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Advanced glycosylation endproduct receptor signaling pathway
Apoptotic execution phase pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MyD88 dependent cascade initiated on endosome pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Innate Immune System pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
RIP-mediated NFkB activation via ZBP1 pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Apoptosis pathway
MyD88 cascade initiated on plasma membrane pathway
KEGG
Base excision repair pathway
INOH
PID BIOCARTA
The information processing pathway at the ifn beta enhancer [Biocarta view]
Apoptotic dna-fragmentation and tissue homeostasis [Biocarta view]
PID NCI
Beta3 integrin cell surface interactions
amb2 Integrin signaling
Endogenous TLR signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.207047 Mm.402118 Mm.437213 Mm.455366 Mm.461535 Mm.470617
RefSeq NM_010439 XM_003945339 XM_006517801 XM_006543113 XM_006544655
OMIM
CCDS CCDS19883
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas