InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Alox5ap

Summary

InnateDB Gene

IDBG-209378.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alox5ap

Gene Name

arachidonate 5-lipoxygenase activating protein

Synonyms

Flap

Species

Mus musculus

Ensembl Gene

ENSMUSG00000060063

Encoded Proteins

IDBP-209380

arachidonate 5-lipoxygenase activating protein

IDBP-533462

arachidonate 5-lipoxygenase activating protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132965:
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:149265058-149288045

Strand

Forward strand

Band

Transcripts

ENSMUST00000071130	ENSMUSP00000071130
ENSMUST00000130144	ENSMUSP00000119413

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004051	arachidonate 5-lipoxygenase activity
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding
GO:0050544	arachidonic acid binding

Biological Process

GO:0002540	leukotriene production involved in inflammatory response
GO:0002675	positive regulation of acute inflammatory response
GO:0019370	leukotriene biosynthetic process
GO:0043085	positive regulation of catalytic activity
GO:0055114	oxidation-reduction process
GO:0070207	protein homotrimerization
GO:0071277	cellular response to calcium ion

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane