InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lat

Summary

InnateDB Gene

IDBG-209436.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lat

Gene Name

linker for activation of T cells

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030742

Encoded Proteins

IDBP-209438

linker for activation of T cells

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 12857726

[Homo sapiens] LAT dephosphorylation in human platelets is integrin-mediated and involves PTPN1 protein tyrosine phosphatase and both PTPN1 activation and LAT dephosphorylation processes were involved in the control of irreversible platelet aggregation upon FcgammaRIIa stimulation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213658:
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:126363832-126369543

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032997

ENSMUSP00000032997

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0002260	lymphocyte homeostasis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0006968	cellular defense response
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0007265	Ras protein signal transduction
GO:0009967	positive regulation of signal transduction
GO:0010467	gene expression
GO:0019722	calcium-mediated signaling
GO:0035556	intracellular signal transduction
GO:0043303	mast cell degranulation
GO:0048872	homeostasis of number of cells
GO:0050863	regulation of T cell activation

Cellular Component

GO:0001772	immunological synapse
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0008180	COP9 signalosome
GO:0016021	integral component of membrane
GO:0042629	mast cell granule