InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Itga3

Summary

InnateDB Gene

IDBG-209447.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itga3

Gene Name

integrin alpha 3

Synonyms

AA407068; CD49C; GAPB3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001507

Encoded Proteins

IDBP-209451

integrin alpha 3

IDBP-266022

integrin alpha 3

IDBP-400078

integrin alpha 3

IDBP-534027

integrin alpha 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20877569

[Homo sapiens] ITGA3 along with ITGB1 is a novel regulator for the recognition of bacterial lipopeptides. ITGA3/ITGB1 integrin regulates endosomal Toll-like receptor (TLR)-2/TLR1 signalling, serving as a mechanism for modulating inflammatory responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005884:
The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:95044474-95076801

Strand

Reverse strand

Band

Transcripts

ENSMUST00000001548	ENSMUSP00000001548
ENSMUST00000107739	ENSMUSP00000103368
ENSMUST00000120375	ENSMUSP00000113556
ENSMUST00000141693
ENSMUST00000140342
ENSMUST00000145671	ENSMUSP00000115970

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0019904	protein domain specific binding
GO:0043236	laminin binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001764	neuron migration
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007507	heart development
GO:0007613	memory
GO:0010628	positive regulation of gene expression
GO:0010634	positive regulation of epithelial cell migration
GO:0010811	positive regulation of cell-substrate adhesion
GO:0010976	positive regulation of neuron projection development
GO:0031345	negative regulation of cell projection organization
GO:0034698	response to gonadotropin
GO:0042493	response to drug
GO:0060135	maternal process involved in female pregnancy

Cellular Component

GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016323	basolateral plasma membrane
GO:0030426	growth cone
GO:0034667	integrin alpha3-beta1 complex
GO:0043235	receptor complex
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome