Version 5.4
Mus musculus Gene: Nsfl1c
Summary
InnateDB Gene IDBG-209481.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nsfl1c
Gene Name NSFL1 (p97) cofactor (p47)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000027455
Encoded Proteins
IDBP-209483
NSFL1 (p97) cofactor (p47)
IDBP-209485
NSFL1 (p97) cofactor (p47)
IDBP-209487
NSFL1 (p97) cofactor (p47)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088833:
N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:151494182-151511414
Strand Forward strand
Band G3
Transcripts
ENSMUST00000103160 ENSMUSP00000099449
ENSMUST00000028949 ENSMUSP00000028949
ENSMUST00000089140 ENSMUSP00000086542
ENSMUST00000153333
ENSMUST00000125270
ENSMUST00000133197
ENSMUST00000156182
ENSMUST00000146695
ENSMUST00000134081
ENSMUST00000139229
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005795 Golgi stack
GO:0005886 plasma membrane
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000088833
View Gene Order
ENSBTAG00000006533
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.389629 Mm.419479
RefSeq NM_001291074 NM_198326 XM_006499844
OMIM
CCDS CCDS16868 CCDS71160
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca