InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sh2b1

Summary

InnateDB Gene

IDBG-209516.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sh2b1

Gene Name

SH2B adaptor protein 1

Synonyms

AI425885; C530001K22Rik; Irip; mKIAA1299; Psm; SH2-B; SH2-Bb; Sh2bpsm1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030733

Encoded Proteins

IDBP-209518

SH2B adaptor protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178188:
This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:126466994-126475130

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032978

ENSMUSP00000032978

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding

Biological Process

GO:0006928	cellular component movement
GO:0030032	lamellipodium assembly
GO:0035556	intracellular signal transduction
GO:0045840	positive regulation of mitosis
GO:2000278	regulation of DNA biosynthetic process