Version 5.4
Mus musculus Gene: Rfc3
Summary
InnateDB Gene IDBG-209720.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rfc3
Gene Name replication factor C (activator 1) 3
Synonyms 2810416I22Rik; 38kDa; AU022547; Recc3
Species Mus musculus
Ensembl Gene ENSMUSG00000033970
Encoded Proteins
IDBP-209722
replication factor C (activator 1) 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133119:
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:151642756-151651242
Strand Reverse strand
Band G3
Transcripts
ENSMUST00000038131 ENSMUSP00000039621
ENSMUST00000127366
ENSMUST00000156667
ENSMUST00000145106
ENSMUST00000140067
ENSMUST00000132709
ENSMUST00000136752
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
GO:0046683 response to organophosphorus
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000133119
View Gene Order
ENSBTAG00000010787
Not yet available
Pathways
NETPATH
REACTOME
REACT_213655
Transcription-coupled NER (TC-NER) pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_202316
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_233453
Chromosome Maintenance pathway
REACT_258062
Synthesis of DNA pathway
REACT_241296
DNA strand elongation pathway
REACT_219381
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_232628
DNA Replication pathway
REACT_238177
Global Genomic NER (GG-NER) pathway
REACT_237585
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_252672
Telomere Maintenance pathway
REACT_188804
Cell Cycle pathway
REACT_235422
Nucleotide Excision Repair pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_209299
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_233397
DNA Repair pathway
REACT_259967
Leading Strand Synthesis pathway
REACT_220175
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_235397
G2/M Checkpoints pathway
REACT_252545
Extension of Telomeres pathway
REACT_245471
Polymerase switching pathway
REACT_232236
Activation of ATR in response to replication stress pathway
REACT_245263
Lagging Strand Synthesis pathway
REACT_225604
Polymerase switching on the C-strand of the telomere pathway
REACT_253623
S Phase pathway
KEGG
mmu03030
DNA replication pathway
mmu03420
Nucleotide excision repair pathway
mmu03430
Mismatch repair pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_7987
Polymerase switching on the C-strand of the telomere pathway
REACT_7961
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_1792
Polymerase switching pathway
REACT_1838
Leading Strand Synthesis pathway
REACT_1993
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_74
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_1628
Transcription-coupled NER (TC-NER) pathway
REACT_378
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_1998
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_899
S Phase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_828
G2/M Checkpoints pathway
REACT_2253
Global Genomic NER (GG-NER) pathway
REACT_7970
Telomere Maintenance pathway
REACT_115566
Cell Cycle pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_8030
Extension of Telomeres pathway
REACT_312
Lagging Strand Synthesis pathway
REACT_1826
Nucleotide Excision Repair pathway
REACT_216
DNA Repair pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_225014
S Phase pathway
REACT_217593
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_209654
Extension of Telomeres pathway
REACT_227775
Transcription-coupled NER (TC-NER) pathway
REACT_213604
DNA Replication pathway
REACT_221747
Telomere Maintenance pathway
REACT_221748
Polymerase switching on the C-strand of the telomere pathway
REACT_214597
Leading Strand Synthesis pathway
REACT_212448
Nucleotide Excision Repair pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_214477
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_222458
Global Genomic NER (GG-NER) pathway
REACT_202907
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_224922
Synthesis of DNA pathway
REACT_214934
Cell Cycle pathway
REACT_204262
DNA Repair pathway
REACT_214081
Lagging Strand Synthesis pathway
REACT_227796
Chromosome Maintenance pathway
REACT_206537
G2/M Checkpoints pathway
REACT_227740
Activation of ATR in response to replication stress pathway
REACT_222741
Polymerase switching pathway
REACT_207824
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_224819
Cell Cycle Checkpoints pathway
REACT_212930
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_203054
DNA strand elongation pathway
KEGG
hsa03030
DNA replication pathway
hsa03420
Nucleotide excision repair pathway
hsa03430
Mismatch repair pathway
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
atr_pathway
ATR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.12553 Mm.400511
RefSeq NM_027009 XM_006504939
OMIM
CCDS CCDS39413
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca