Mus musculus Gene: Kat8
Summary
InnateDB Gene IDBG-210450.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kat8
Gene Name K(lysine) acetyltransferase 8
Synonyms 2010203C02Rik; 5830450F21Rik; D7Ertd629e; MOF; Myst1
Species Mus musculus
Ensembl Gene ENSMUSG00000030801
Encoded Proteins
MYST histone acetyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103510:
This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:127912517-127925832
Strand Forward strand
Band F3
Transcripts
ENSMUST00000033070 ENSMUSP00000033070
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016407 acetyltransferase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0019899 enzyme binding
GO:0035064 methylated histone binding
GO:0043995 histone acetyltransferase activity (H4-K5 specific)
GO:0043996 histone acetyltransferase activity (H4-K8 specific)
GO:0046872 metal ion binding
GO:0046972 histone acetyltransferase activity (H4-K16 specific)
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016573 histone acetylation
GO:0030099 myeloid cell differentiation
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043984 histone H4-K16 acetylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0031965 nuclear membrane
GO:0071339 MLL1 complex
GO:0072487 MSL complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Chromatin organization pathway
HATs acetylate histones pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
HATs acetylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
p53 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.425492
RefSeq NM_026370 XM_006508138
OMIM
CCDS CCDS21885
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas