InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Med24

Summary

InnateDB Gene

IDBG-210636.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Med24

Gene Name

mediator complex subunit 24

Synonyms

911GSE; AU040102; AW547152; D11Ertd307e; DRIP100; Gse2; Pparb2; Pparbp2; R75526; Thrap4; Trap100

Species

Mus musculus

Ensembl Gene

ENSMUSG00000017210

Encoded Proteins

IDBP-210638

mediator complex subunit 24

IDBP-210642

mediator complex subunit 24

IDBP-535386

mediator complex subunit 24

IDBP-536105

mediator complex subunit 24

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene may form a submodule of the mediator complex that magnifies the effects of activators on the general transcription machinery. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:98704591-98729435

Strand

Reverse strand

Band

Transcripts

ENSMUST00000017354	ENSMUSP00000017354
ENSMUST00000100500	ENSMUSP00000098069
ENSMUST00000125064
ENSMUST00000156378
ENSMUST00000138750	ENSMUSP00000120002
ENSMUST00000124371
ENSMUST00000139849
ENSMUST00000137328
ENSMUST00000144720
ENSMUST00000141566
ENSMUST00000126565	ENSMUSP00000118820
ENSMUST00000144048

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	58 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0004872	receptor activity
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0016573	histone acetylation
GO:0019827	stem cell maintenance
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051291	protein heterooligomerization