InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ctbp2

Summary

InnateDB Gene

IDBG-211193.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctbp2

Gene Name

C-terminal binding protein 2

Synonyms

AA407280; D7Ertd45e; Gtrgeo6; Ribeye

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030970

Encoded Proteins

IDBP-211195

C-terminal binding protein 2

IDBP-624391

C-terminal binding protein 2

IDBP-624368

C-terminal binding protein 2

IDBP-624375

C-terminal binding protein 2

IDBP-624376

C-terminal binding protein 2

IDBP-624377

C-terminal binding protein 2

IDBP-624378

C-terminal binding protein 2

IDBP-624381

C-terminal binding protein 2

IDBP-624386

C-terminal binding protein 2

IDBP-624387

C-terminal binding protein 2

IDBP-624390

C-terminal binding protein 2

IDBP-624392

C-terminal binding protein 2

IDBP-624393

C-terminal binding protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175029:
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. [provided by RefSeq, Jul 2008]
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3\' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:132987563-133124354

Strand

Reverse strand

Band

Transcripts

ENSMUST00000033269	ENSMUSP00000033269
ENSMUST00000155996	ENSMUSP00000132558
ENSMUST00000165457	ENSMUSP00000126126
ENSMUST00000169570	ENSMUSP00000130294
ENSMUST00000166439	ENSMUSP00000127448
ENSMUST00000168958	ENSMUSP00000132892
ENSMUST00000172341	ENSMUSP00000127701
ENSMUST00000165534
ENSMUST00000166400
ENSMUST00000163601	ENSMUSP00000128944
ENSMUST00000171727
ENSMUST00000164739
ENSMUST00000164896
ENSMUST00000167218	ENSMUSP00000133269
ENSMUST00000170459	ENSMUSP00000129590
ENSMUST00000171882	ENSMUSP00000129312
ENSMUST00000171022	ENSMUSP00000132399
ENSMUST00000171968	ENSMUSP00000130727
ENSMUST00000168762
ENSMUST00000168238

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	56 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287	NAD binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0008152	metabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050872	white fat cell differentiation
GO:0055114	oxidation-reduction process