InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Jup

Summary

InnateDB Gene

IDBG-211364.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Jup

Gene Name

junction plakoglobin

Synonyms

Ctnng; D930025P04Rik; PG

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001552

Encoded Proteins

IDBP-211366

junction plakoglobin

IDBP-266745

junction plakoglobin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173801:
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:100368958-100397763

Strand

Reverse strand

Band

Transcripts

ENSMUST00000001592	ENSMUSP00000001592
ENSMUST00000107403	ENSMUSP00000103026
ENSMUST00000124659
ENSMUST00000151476
ENSMUST00000152774
ENSMUST00000149798
ENSMUST00000155746
ENSMUST00000128268
ENSMUST00000123903

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005198	structural molecule activity
GO:0005488	binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0045294	alpha-catenin binding
GO:0045296	cadherin binding

Biological Process

GO:0000902	cell morphogenesis
GO:0002159	desmosome assembly
GO:0003136	negative regulation of heart induction by canonical Wnt receptor signaling pathway
GO:0003181	atrioventricular valve morphogenesis
GO:0003308	negative regulation of Wnt receptor signaling pathway involved in heart development
GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0007155	cell adhesion
GO:0007369	gastrulation
GO:0007398	ectoderm development
GO:0007399	nervous system development
GO:0016331	morphogenesis of embryonic epithelium
GO:0016337	single organismal cell-cell adhesion
GO:0016477	cell migration
GO:0042127	regulation of cell proliferation
GO:0042307	positive regulation of protein import into nucleus
GO:0043588	skin development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048599	oocyte development
GO:0050982	detection of mechanical stimulus
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051291	protein heterooligomerization
GO:0071681	cellular response to indole-3-methanol
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086069	bundle of His cell to Purkinje myocyte communication
GO:0086091	regulation of heart rate by cardiac conduction
GO:0090002	establishment of protein localization to plasma membrane

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005882	intermediate filament
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005913	cell-cell adherens junction
GO:0005915	zonula adherens
GO:0005916	fascia adherens
GO:0009898	cytoplasmic side of plasma membrane
GO:0014704	intercalated disc
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016327	apicolateral plasma membrane
GO:0016328	lateral plasma membrane
GO:0016342	catenin complex
GO:0030018	Z disc
GO:0030057	desmosome
GO:0030877	beta-catenin destruction complex
GO:0032993	protein-DNA complex
GO:0070062	extracellular vesicular exosome
GO:0071665	gamma-catenin-TCF7L2 complex