Mus musculus Gene: Glrx3
Summary
InnateDB Gene IDBG-211431.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Glrx3
Gene Name glutaredoxin 3
Synonyms PICOT; Txnl2;
Species Mus musculus
Ensembl Gene ENSMUSG00000031068
Encoded Proteins
glutaredoxin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108010:
This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:137437648-137468594
Strand Forward strand
Band F4
Transcripts
ENSMUST00000064404 ENSMUSP00000066621
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0015035 protein disulfide oxidoreductase activity
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0007067 mitotic nuclear division
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005681 spliceosomal complex
GO:0005938 cell cortex
GO:0030018 Z disc
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt Q9CQM9
TrEMBL
UniProt Splice Variant
Entrez Gene 30926
UniGene
RefSeq NM_023140
OMIM
CCDS CCDS21948
HPRD
IMGT
MGI ID MGI:1353653
MGI Symbol Glrx3
EMBL AF118650 AK010354 AK017371 AK147158 AK152446 AK152634 AK155190 AK167672 BC033506 BC087885
GenPept AAF28842 AAH33506 AAH87885 BAB26874 BAB30712 BAE27724 BAE31225 BAE31376 BAE33105 BAE39721
RNA Seq Atlas 30926