InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Stat3

Summary

InnateDB Gene

IDBG-211637.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stat3

Gene Name

signal transducer and activator of transcription 3

Synonyms

1110034C02Rik; Aprf; AW109958

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004040

Encoded Proteins

IDBP-211639

signal transducer and activator of transcription 3

IDBP-211643

signal transducer and activator of transcription 3

IDBP-537102

signal transducer and activator of transcription 3

IDBP-533033

signal transducer and activator of transcription 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21810606

Stat3 is a negative regulator of type I IFN-mediated anti-viral responses.

PMID 23460517

STAT3 mediates protein transport and secretion in hepatocytes during the acute phase of pneumonia.

PMID 24412612

Stat3 mediates protection against intestinal infection by inducing innate lymphoid cell derived-Il22.

PMID 25692402

Stat3 is required for maximal Osm-induced lung Cxcl5 expression and subsequent neutrophil recruitment during bacterial pneumonia.

InnateDB Annotation from Orthologs

Summary

PMID 17971840

[Homo sapiens] STAT3 is a transcription factor that mediates interleukin-10 (IL-10) cytokine signalling.

PMID 19667404

[Homo sapiens] STAT3 and SRC have a role in the immunoregulation of dendritic cells (DCs) where apoptotic cells-induced inhibition of dendritic cells (DCs) requires MerTK-dependent activation of SRC and STAT3.

PMID 20040863

[Homo sapiens] STAT3 mediates mucosa-protective and anti-inflammatory functions in epithelial and myeloid cells and promotes inflammation in T cells.

PMID 20493732

[Homo sapiens] STAT3 binds to multiple genes involved in Th17 cell differentiation, cell activation, proliferation, and survival, regulating both expression, epigenetic modifications, and targets the T cell function in inflammation and homeostasis.

PMID 20581311

[Homo sapiens] STAT3 is an essential mediator of emergency granulopoiesis via its regulation of transcription factors CEBPA and CEBPB that direct granulocyte colony-stimulating factor (G-CSF)-responsive myeloid progenitor expansion.

PMID 21810606

[Homo sapiens] STAT3 is a negative regulator of type I IFN-mediated anti-viral responses. (Demonstrated in mouse)

PMID 25510212

[Homo sapiens] In alveolar epithelium, IL22 upregulates DEFB4A gene expression via STAT3.

PMID 26535690

[Homo sapiens] MIR29A inhibits IL10-induced cytokine release by targeting JAK-STAT3 in monocytes during sepsis.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168610:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:100885098-100939540

Strand

Reverse strand

Band

Transcripts

ENSMUST00000103114	ENSMUSP00000099403
ENSMUST00000092671	ENSMUSP00000090342
ENSMUST00000127638	ENSMUSP00000120152
ENSMUST00000137093
ENSMUST00000138438	ENSMUSP00000121677
ENSMUST00000152601
ENSMUST00000155972
ENSMUST00000137367
ENSMUST00000156645
ENSMUST00000151544
ENSMUST00000146971
ENSMUST00000154170
ENSMUST00000152623
ENSMUST00000130686

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 349 experimentally validated interaction(s) in this database.
They are also associated with 196 interaction(s) predicted by orthology.

Experimentally validated
Total	349 [view]
Protein-Protein	235 [view]
Protein-DNA	111 [view]
Protein-RNA	2 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	196 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0031730	CCR5 chemokine receptor binding
GO:0035259	glucocorticoid receptor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001659	temperature homeostasis
GO:0001754	eye photoreceptor cell differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006606	protein import into nucleus
GO:0006953	acute-phase response
GO:0007165	signal transduction
GO:0007259	JAK-STAT cascade
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010033	response to organic substance
GO:0014070	response to organic cyclic compound
GO:0016310	phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0019827	stem cell maintenance
GO:0019953	sexual reproduction
GO:0030522	intracellular receptor signaling pathway
GO:0032355	response to estradiol
GO:0032870	cellular response to hormone stimulus
GO:0034097	response to cytokine
GO:0040014	regulation of multicellular organism growth
GO:0042493	response to drug
GO:0042593	glucose homeostasis
GO:0042755	eating behavior
GO:0043434	response to peptide hormone
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045747	positive regulation of Notch signaling pathway
GO:0045820	negative regulation of glycolytic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048708	astrocyte differentiation
GO:0060019	radial glial cell differentiation
GO:0060396	growth hormone receptor signaling pathway
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060548	negative regulation of cell death
GO:0070102	interleukin-6-mediated signaling pathway
GO:2001223	negative regulation of neuron migration