Version 5.4
Mus musculus Gene: Pkig
Summary
InnateDB Gene IDBG-211949.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pkig
Gene Name protein kinase inhibitor, gamma
Synonyms PKIgamma
Species Mus musculus
Ensembl Gene ENSMUSG00000035268
Encoded Proteins
IDBP-211951
protein kinase inhibitor, gamma
IDBP-211953
protein kinase inhibitor, gamma
IDBP-262472
protein kinase inhibitor, gamma
IDBP-537578
protein kinase inhibitor, gamma
IDBP-533146
protein kinase inhibitor, gamma
IDBP-534313
protein kinase inhibitor, gamma
IDBP-536273
protein kinase inhibitor, gamma
IDBP-624011
protein kinase inhibitor, gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168734:
The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive PKA inhibitor, and is a predominant form of PKA inhibitors in various tissues. Three alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
This gene encodes a member of the protein kinase inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive cAMP-dependent protein kinase inhibitor, and is a predominant form of inhibitor in various tissues. The encoded protein may be involved in osteogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:163658386-163726158
Strand Forward strand
Band H3
Transcripts
ENSMUST00000064703 ENSMUSP00000068344
ENSMUST00000099105 ENSMUSP00000096704
ENSMUST00000109400 ENSMUSP00000105027
ENSMUST00000147385
ENSMUST00000152418 ENSMUSP00000121956
ENSMUST00000126182 ENSMUSP00000120145
ENSMUST00000131228 ENSMUSP00000120355
ENSMUST00000135537 ENSMUSP00000114291
ENSMUST00000164399 ENSMUSP00000126223
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004862 cAMP-dependent protein kinase inhibitor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006469 negative regulation of protein kinase activity
GO:0007165 signal transduction
GO:0042308 negative regulation of protein import into nucleus
GO:0071901 negative regulation of protein serine/threonine kinase activity
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000168734
View Gene Order
ENSBTAG00000005275
Not yet available
Cross-References
SwissProt
TrEMBL B7ZC21 B7ZC22
UniProt Splice Variant
Entrez Gene 18769
UniGene Mm.10091 Mm.415944
RefSeq NM_001039390 NM_001039391 NM_001164053 NM_001164055 NM_001277096 NM_011106 XM_006498926
OMIM
CCDS CCDS17014
HPRD
IMGT
MGI ID MGI:1343086
MGI Symbol Pkig
EMBL AL591490
GenPept
RNA Seq Atlas 18769

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca