InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RCOR1

Summary

InnateDB Gene

IDBG-21216.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RCOR1

Gene Name

REST corepressor 1

Synonyms

COREST; RCOR

Species

Homo sapiens

Ensembl Gene

ENSG00000089902

Encoded Proteins

IDBP-21218

REST corepressor 1

IDBP-594228

REST corepressor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20798038

Co-repressor of REST (RCOR1) is part of a repressor complex, along with key components that include histone deacetylase 1 or 2, RE-1 silencing transcription factor (REST), and lysine-specific demethylase (LSD) 1. The HDAC/RCOR1/REST/LSD1 repressor complex is a significant component of host innate immunity.

Entrez Gene

Summary

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:102592661-102730576

Strand

Forward strand

Band

q32.31

Transcripts

ENST00000262241	ENSP00000262241
ENST00000558495
ENST00000559597
ENST00000560472	ENSP00000454204

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	72 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007596	blood coagulation
GO:0016032	viral process
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0070933	histone H4 deacetylation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0017053	transcriptional repressor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000037896

View Gene Order

ENSBTAG00000002336

Not yet available

Pathways

NETPATH

REACTOME

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_228222

HDACs deacetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

REACT_604

Hemostasis pathway

KEGG

hsa05016

Huntington's disease pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.510521 Hs.626437

RefSeq

NM_015156 XM_005267453

HUGO

OMIM

CCDS

CCDS9974

HPRD

09645

IMGT

EMBL

GenPept

RNA Seq Atlas