Homo sapiens Gene: RCOR1
Summary
InnateDB Gene IDBG-21216.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RCOR1
Gene Name REST corepressor 1
Synonyms COREST; RCOR;
Species Homo sapiens
Ensembl Gene ENSG00000089902
Encoded Proteins
REST corepressor 1
REST corepressor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Co-repressor of REST (RCOR1) is part of a repressor complex, along with key components that include histone deacetylase 1 or 2, RE-1 silencing transcription factor (REST), and lysine-specific demethylase (LSD) 1. The HDAC/RCOR1/REST/LSD1 repressor complex is a significant component of host innate immunity.
Entrez Gene
Summary This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:102592661-102730576
Strand Forward strand
Band q32.31
Transcripts
ENST00000262241 ENSP00000262241
ENST00000558495
ENST00000559597
ENST00000560472 ENSP00000454204
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 75 [view]
Protein-Protein 72 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007596 blood coagulation
GO:0016032 viral process
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0070933 histone H4 deacetylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
HDACs deacetylate histones pathway
Chromatin organization pathway
Factors involved in megakaryocyte development and platelet production pathway
Chromatin modifying enzymes pathway
Hemostasis pathway
KEGG
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.510521 Hs.626437
RefSeq NM_015156 XM_005267453
HUGO
OMIM
CCDS CCDS9974
HPRD 09645
IMGT
EMBL
GenPept
RNA Seq Atlas