Version 5.4
Mus musculus Gene: Eps8l2
Summary
InnateDB Gene IDBG-212161.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eps8l2
Gene Name EPS8-like 2
Synonyms AI042819; AW545405; Eps8r2
Species Mus musculus
Ensembl Gene ENSMUSG00000025504
Encoded Proteins
IDBP-212163
EPS8-like 2
IDBP-535172
EPS8-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177106:
This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:141338880-141363020
Strand Forward strand
Band F5
Transcripts
ENSMUST00000026577 ENSMUSP00000026577
ENSMUST00000140025
ENSMUST00000145108
ENSMUST00000136736
ENSMUST00000143633 ENSMUSP00000120726
ENSMUST00000146042
ENSMUST00000127501
ENSMUST00000136240
ENSMUST00000133669
ENSMUST00000155729
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
GO:0051015 actin filament binding
Biological Process
GO:0007266 Rho protein signal transduction
GO:0016601 Rac protein signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:1900029 positive regulation of ruffle assembly
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0032587 ruffle membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000177106
View Gene Order
ENSBTAG00000022147
Not yet available
Cross-References
SwissProt Q99K30
TrEMBL D3YWI5
UniProt Splice Variant
Entrez Gene 98845
UniGene Mm.27451
RefSeq NM_133191
OMIM
CCDS CCDS22009
HPRD
IMGT
MGI ID MGI:2138828
MGI Symbol Eps8l2
EMBL AC163434 BC005492 BC009098
GenPept AAH05492 AAH09098
RNA Seq Atlas 98845

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca