InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lrdd

Summary

InnateDB Gene

IDBG-212221.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrdd

Gene Name

leucine-rich and death domain containing

Synonyms

1200011D09Rik; AU042446; Lrdd; Pidd

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025507

Encoded Proteins

IDBP-212223

leucine-rich and death domain containing

IDBP-269680

leucine-rich and death domain containing

IDBP-790083

p53 induced death domain protein 1

IDBP-790081

p53 induced death domain protein 1

IDBP-790084

p53 induced death domain protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177595:
The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:141438113-141444025

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026580	ENSMUSP00000026580
ENSMUST00000106005	ENSMUSP00000101627
ENSMUST00000154949
ENSMUST00000131980
ENSMUST00000128703	ENSMUSP00000139487
ENSMUST00000147268
ENSMUST00000138065
ENSMUST00000131621
ENSMUST00000130878
ENSMUST00000190068	ENSMUSP00000139957
ENSMUST00000190882	ENSMUSP00000139785
ENSMUST00000190303

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007165	signal transduction
GO:0043066	negative regulation of apoptotic process
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001235	positive regulation of apoptotic signaling pathway
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000177595

View Gene Order

ENSBTAG00000019634

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04115

p53 signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04115

p53 signaling pathway pathway

INOH

PID NCI

caspase_pathway

Caspase Cascade in Apoptosis

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_022654 XM_006536218 XM_006536220 XM_006536221

OMIM

CCDS

CCDS22014

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas