InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Acot8

Summary

InnateDB Gene

IDBG-212349.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acot8

Gene Name

acyl-CoA thioesterase 8

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000017307

Encoded Proteins

IDBP-212351

acyl-CoA thioesterase 8

IDBP-212353

acyl-CoA thioesterase 8

IDBP-624243

acyl-CoA thioesterase 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101473:
The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:164792768-164804882

Strand

Reverse strand

Band

Transcripts

ENSMUST00000017451	ENSMUSP00000017451
ENSMUST00000103094	ENSMUSP00000099383
ENSMUST00000133053
ENSMUST00000136767
ENSMUST00000134611	ENSMUSP00000133718

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0016290	palmitoyl-CoA hydrolase activity
GO:0033882	choloyl-CoA hydrolase activity
GO:0047617	acyl-CoA hydrolase activity
GO:0052815	medium-chain acyl-CoA hydrolase activity