InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ascl2

Summary

InnateDB Gene

IDBG-212651.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ascl2

Gene Name

achaete-scute complex homolog 2 (Drosophila)

Synonyms

2410083I15Rik; bHLHa45; Mash2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000009248

Encoded Proteins

IDBP-212653

achaete-scute complex homolog 2 (Drosophila)

IDBP-400118

achaete-scute complex homolog 2 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183734:
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008]
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5\'-CANNTG-3\'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:142966822-142969264

Strand

Reverse strand

Band

Transcripts

ENSMUST00000009392	ENSMUSP00000009392
ENSMUST00000121862	ENSMUSP00000113012

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0001890	placenta development
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0010626	negative regulation of Schwann cell proliferation
GO:0030154	cell differentiation
GO:0035019	somatic stem cell maintenance
GO:0060708	spongiotrophoblast differentiation
GO:0060712	spongiotrophoblast layer development

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000183734

View Gene Order

ENSBTAG00000026769

Not yet available

Cross-References

SwissProt

TrEMBL

D3Z7Q6

UniProt Splice Variant

Entrez Gene

17173

UniGene

Mm.196417

RefSeq

NM_008554 XM_006508498

OMIM

CCDS

CCDS40194

HPRD

IMGT

MGI ID

MGI:96920

MGI Symbol

Ascl2

EMBL

AC015800

GenPept

RNA Seq Atlas

17173