InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cd81

Summary

InnateDB Gene

IDBG-212677.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd81

Gene Name

CD81 antigen

Synonyms

Tapa-1; Tapa1; Tspan28

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037706

Encoded Proteins

IDBP-212679

CD81 antigen

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25972472

Cd81 inhibits Rac1/Stat1 activation and negatively regulates the defence mechanisms to Listeria monocytogenes infection.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110651:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:143052739-143067934

Strand

Forward strand

Band

Transcripts

ENSMUST00000037941	ENSMUSP00000043768
ENSMUST00000128762
ENSMUST00000141954
ENSMUST00000132303

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0023026	MHC class II protein complex binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0006661	phosphatidylinositol biosynthetic process
GO:0008104	protein localization
GO:0008284	positive regulation of cell proliferation
GO:0030307	positive regulation of cell growth
GO:0030890	positive regulation of B cell proliferation
GO:0043128	positive regulation of 1-phosphatidylinositol 4-kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0046488	phosphatidylinositol metabolic process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation

Cellular Component

GO:0001772	immunological synapse
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031982	vesicle
GO:0070062	extracellular vesicular exosome