InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Eftud2

Summary

InnateDB Gene

IDBG-212804.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eftud2

Gene Name

elongation factor Tu GTP binding domain containing 2

Synonyms

116kDa; Snrp116; U5-116kD

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020929

Encoded Proteins

IDBP-212806

elongation factor Tu GTP binding domain containing 2

IDBP-267452

elongation factor Tu GTP binding domain containing 2

IDBP-620131

elongation factor Tu GTP binding domain containing 2

IDBP-620133

elongation factor Tu GTP binding domain containing 2

IDBP-620129

elongation factor Tu GTP binding domain containing 2

IDBP-620130

elongation factor Tu GTP binding domain containing 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25878102

[Homo sapiens] EFTUD2 is a novel innate immune regulator that restricts hepatitis C virus infection through an RIG-I/MDA5-mediated, JAK-STAT-independent pathway.

PMID 25878102

[Homo sapiens] EFTUD2 is a novel innate immune antiviral regulator that restricts hepatitis C virus infection through a DDX58/IFIH1-mediated, JAK-STAT-independent pathway.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108883:
This gene encodes a GTPase which is a component of the spliceosome complex which processes precursor mRNAs to produce mature mRNAs. Mutations in this gene are associated with mandibulofacial dysostosis with microcephaly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:102838473-102880985

Strand

Reverse strand

Band

Transcripts

ENSMUST00000021306	ENSMUSP00000021306
ENSMUST00000107060	ENSMUSP00000102675
ENSMUST00000132543	ENSMUSP00000133732
ENSMUST00000143323
ENSMUST00000141273
ENSMUST00000131678
ENSMUST00000138483	ENSMUSP00000134725
ENSMUST00000123833
ENSMUST00000147368
ENSMUST00000148209
ENSMUST00000172611	ENSMUSP00000134316
ENSMUST00000173679	ENSMUSP00000134327
ENSMUST00000173974

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	92 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003746	translation elongation factor activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006397	mRNA processing
GO:0006414	translational elongation
GO:0007264	small GTPase mediated signal transduction
GO:0008380	RNA splicing

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0015030	Cajal body
GO:0016020	membrane
GO:0016607	nuclear speck
GO:0071013	catalytic step 2 spliceosome