InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ncoa3

Summary

InnateDB Gene

IDBG-212832.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ncoa3

Gene Name

nuclear receptor coactivator 3

Synonyms

2010305B15Rik; Actr; Aib1; AW321064; bHLHe42; KAT13B; p/Cip; pCip; Rac3; Src3; Tram-1; Tram1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027678

Encoded Proteins

IDBP-212834

nuclear receptor coactivator 3

IDBP-262781

nuclear receptor coactivator 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124151:
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:165992636-166073242

Strand

Forward strand

Band

Transcripts

ENSMUST00000088095	ENSMUSP00000085416
ENSMUST00000109252	ENSMUSP00000104875
ENSMUST00000153507
ENSMUST00000139658
ENSMUST00000139394

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 112 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	45 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	112 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0035257	nuclear hormone receptor binding
GO:0046983	protein dimerization activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0010628	positive regulation of gene expression
GO:0016573	histone acetylation
GO:0035264	multicellular organism growth
GO:0045618	positive regulation of keratinocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048589	developmental growth
GO:0060068	vagina development
GO:0060713	labyrinthine layer morphogenesis
GO:0060744	mammary gland branching involved in thelarche
GO:2001141	regulation of RNA biosynthetic process