InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cttn

Summary

InnateDB Gene

IDBG-212876.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cttn

Gene Name

cortactin

Synonyms

1110020L01Rik; Ems1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031078

Encoded Proteins

IDBP-212878

cortactin

IDBP-212884

cortactin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085733:
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:144435733-144471009

Strand

Reverse strand

Band

Transcripts

ENSMUST00000103079	ENSMUSP00000099368
ENSMUST00000033407	ENSMUSP00000033407
ENSMUST00000134131
ENSMUST00000157079
ENSMUST00000126018
ENSMUST00000150607
ENSMUST00000148778

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Experimentally validated
Total	56 [view]
Protein-Protein	56 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005938	cell cortex
GO:0030027	lamellipodium
GO:0043197	dendritic spine
GO:0070062	extracellular vesicular exosome
GO:1990023	mitotic spindle midzone

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000085733

View Gene Order

ENSBTAG00000006071

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04530

Tight junction pathway

mmu05100

Bacterial invasion of epithelial cells pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

hsa05130

Pathogenic Escherichia coli infection pathway

hsa04530

Tight junction pathway

hsa05100

Bacterial invasion of epithelial cells pathway

hsa05131

Shigellosis pathway

INOH

PID NCI

ecadherin_nascentaj_pathway

E-cadherin signaling in the nascent adherens junction

syndecan_3_pathway

Syndecan-3-mediated signaling events

fgf_pathway

FGF signaling pathway

pdgfrbpathway

PDGFR-beta signaling pathway

ncadherinpathway

N-cadherin signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.399797 Mm.409306 Mm.490123

RefSeq

NM_001252572 NM_007803 XM_006508472 XM_006508474 XM_006508475

OMIM

CCDS

CCDS22049 CCDS57599

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas