InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Crhr1

Summary

InnateDB Gene

IDBG-213083.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crhr1

Gene Name

corticotropin releasing hormone receptor 1

Synonyms

CRFR1; Crhr

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018634

Encoded Proteins

IDBP-213085

corticotropin releasing hormone receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120088:
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants, one of which represents a read-through transcript with the neighboring gene MGC57346. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:104132855-104175523

Strand

Forward strand

Band

Transcripts

ENSMUST00000093925

ENSMUSP00000091455

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0015056	corticotrophin-releasing factor receptor activity
GO:0032403	protein complex binding
GO:0042277	peptide binding
GO:0043404	corticotropin-releasing hormone receptor activity
GO:0051424	corticotropin-releasing hormone binding

Biological Process

GO:0001666	response to hypoxia
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007613	memory
GO:0008542	visual learning
GO:0009755	hormone-mediated signaling pathway
GO:0010578	regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0021854	hypothalamus development
GO:0030325	adrenal gland development
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0030855	epithelial cell differentiation
GO:0032811	negative regulation of epinephrine secretion
GO:0035641	locomotory exploration behavior
GO:0035902	response to immobilization stress
GO:0042596	fear response
GO:0043306	positive regulation of mast cell degranulation
GO:0048148	behavioral response to cocaine
GO:0048149	behavioral response to ethanol
GO:0048167	regulation of synaptic plasticity
GO:0048266	behavioral response to pain
GO:0051458	corticotropin secretion
GO:0051602	response to electrical stimulus
GO:0051867	general adaptation syndrome, behavioral process
GO:0060291	long-term synaptic potentiation
GO:0071376	cellular response to corticotropin-releasing hormone stimulus
GO:1901215	negative regulation of neuron death
GO:1901386	negative regulation of voltage-gated calcium channel activity
GO:2000252	negative regulation of feeding behavior
GO:2000852	regulation of corticosterone secretion

Cellular Component

GO:0005771	multivesicular body
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0031226	intrinsic component of plasma membrane
GO:0031982	vesicle
GO:0043025	neuronal cell body
GO:0045177	apical part of cell