InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Spo11

Summary

InnateDB Gene

IDBG-213339.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spo11

Gene Name

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

Synonyms

AI449549

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005883

Encoded Proteins

IDBP-213341

sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae)

IDBP-263047

sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae)

IDBP-263049

sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000054796:
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5\' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:172977700-172993576

Strand

Forward strand

Band

Transcripts

ENSMUST00000050442	ENSMUSP00000059056
ENSMUST00000109126	ENSMUSP00000104754
ENSMUST00000109125	ENSMUSP00000104753
ENSMUST00000144044
ENSMUST00000156471

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity

Biological Process

GO:0001541	ovarian follicle development
GO:0006259	DNA metabolic process
GO:0007129	synapsis
GO:0007131	reciprocal meiotic recombination
GO:0007141	male meiosis I
GO:0007286	spermatid development
GO:0034502	protein localization to chromosome

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005654	nucleoplasm
GO:0005694	chromosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000054796

View Gene Order

ENSBTAG00000044210

Not yet available

Pathways

NETPATH

REACTOME

REACT_27235

Meiotic Recombination pathway

REACT_200794

Mus musculus biological processes pathway

REACT_188804

Cell Cycle pathway

REACT_198624

Meiosis pathway

REACT_198629

Meiotic recombination pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_27271

Meiotic recombination pathway

REACT_115566

Cell Cycle pathway

REACT_111183

Meiosis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.23495

RefSeq

NM_001083959 NM_001083960 NM_012046 XM_006499621

OMIM

CCDS

CCDS17137 CCDS50811 CCDS50812

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas