Homo sapiens Gene: ARHGDIB
Summary
InnateDB Gene IDBG-21364.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGDIB
Gene Name Rho GDP dissociation inhibitor (GDI) beta
Synonyms D4; GDIA2; GDID4; Ly-GDI; LYGDI; RAP1GN1; RhoGDI2;
Species Homo sapiens
Ensembl Gene ENSG00000111348
Encoded Proteins
Rho GDP dissociation inhibitor (GDI) beta
Rho GDP dissociation inhibitor (GDI) beta
Rho GDP dissociation inhibitor (GDI) beta
Rho GDP dissociation inhibitor (GDI) beta
Rho GDP dissociation inhibitor (GDI) beta
Rho GDP dissociation inhibitor (GDI) beta
Rho GDP dissociation inhibitor (GDI) beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:14942017-14961728
Strand Reverse strand
Band p12.3
Transcripts
ENST00000228945 ENSP00000228945
ENST00000536592 ENSP00000445185
ENST00000541644 ENSP00000444860
ENST00000539131
ENST00000541546 ENSP00000440560
ENST00000545895 ENSP00000445263
ENST00000535676
ENST00000541380 ENSP00000437454
ENST00000542276 ENSP00000445450
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005094 Rho GDP-dissociation inhibitor activity
GO:0005096 GTPase activator activity
Biological Process
GO:0006928 cellular component movement
GO:0006955 immune response
GO:0007162 negative regulation of cell adhesion
GO:0007264 small GTPase mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0007275 multicellular organismal development
GO:0030036 actin cytoskeleton organization
GO:0043547 positive regulation of GTPase activity
GO:0050790 regulation of catalytic activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TCR pathway
REACTOME
Signaling by Rho GTPases pathway
Signal Transduction pathway
Rho GTPase cycle pathway
KEGG
Neurotrophin signaling pathway pathway
Vasopressin-regulated water reabsorption pathway
INOH
PID BIOCARTA
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
D4gdi signaling pathway [Biocarta view]
Caspase cascade in apoptosis [Biocarta view]
PID NCI
Caspase Cascade in Apoptosis
Regulation of RhoA activity
Cross-References
SwissProt P52566
TrEMBL A0A024RAS5 F5H2R5 F5H3P3 F5H6Q0
UniProt Splice Variant
Entrez Gene 397
UniGene Hs.595298
RefSeq NM_001175
HUGO HGNC:679
OMIM 602843
CCDS CCDS8671
HPRD
IMGT
EMBL AB451315 AB451445 AC007655 AF498927 BC009200 CH471094 L07916 L20688 X69549
GenPept AAA59539 AAH09200 AAM21075 BAG70129 BAG70259 CAA49280 EAW96336 EAW96337 EAW96338 EAW96340 EAW96341 EAW96342
RNA Seq Atlas 397