InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARHGDIB

Summary

InnateDB Gene

IDBG-21364.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGDIB

Gene Name

Rho GDP dissociation inhibitor (GDI) beta

Synonyms

D4; GDIA2; GDID4; Ly-GDI; LYGDI; RAP1GN1; RhoGDI2

Species

Homo sapiens

Ensembl Gene

ENSG00000111348

Encoded Proteins

IDBP-21366

Rho GDP dissociation inhibitor (GDI) beta

IDBP-585694

Rho GDP dissociation inhibitor (GDI) beta

IDBP-584279

Rho GDP dissociation inhibitor (GDI) beta

IDBP-598580

Rho GDP dissociation inhibitor (GDI) beta

IDBP-583735

Rho GDP dissociation inhibitor (GDI) beta

IDBP-591974

Rho GDP dissociation inhibitor (GDI) beta

IDBP-584650

Rho GDP dissociation inhibitor (GDI) beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:14942017-14961728

Strand

Reverse strand

Band

p12.3

Transcripts

ENST00000228945	ENSP00000228945
ENST00000536592	ENSP00000445185
ENST00000541644	ENSP00000444860
ENST00000539131
ENST00000541546	ENSP00000440560
ENST00000545895	ENSP00000445263
ENST00000535676
ENST00000541380	ENSP00000437454
ENST00000542276	ENSP00000445450

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005094	Rho GDP-dissociation inhibitor activity
GO:0005096	GTPase activator activity

Biological Process

GO:0006928	cellular component movement
GO:0006955	immune response
GO:0007162	negative regulation of cell adhesion
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0007275	multicellular organismal development
GO:0030036	actin cytoskeleton organization
GO:0043547	positive regulation of GTPase activity
GO:0050790	regulation of catalytic activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030220

View Gene Order

ENSBTAG00000006039

Not yet available

Pathways

NETPATH

NetPath_11

TCR pathway

REACTOME

REACT_11051

Rho GTPase cycle pathway

REACT_11044

Signaling by Rho GTPases pathway

REACT_111102

Signal Transduction pathway

KEGG

hsa04722

Neurotrophin signaling pathway pathway

hsa04962

Vasopressin-regulated water reabsorption pathway

INOH

PID NCI

caspase_pathway

Caspase Cascade in Apoptosis

rhoa_reg_pathway

Regulation of RhoA activity

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.595298

RefSeq

NM_001175

HUGO

OMIM

CCDS

CCDS8671

HPRD

04162

IMGT

EMBL

GenPept

RNA Seq Atlas