Version 5.4
Homo sapiens Gene: DAZL
Summary
InnateDB Gene IDBG-21396.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAZL
Gene Name deleted in azoospermia-like
Synonyms DAZH; DAZL1; DAZLA; SPGYLA
Species Homo sapiens
Ensembl Gene ENSG00000092345
Encoded Proteins
IDBP-21398
deleted in azoospermia-like
IDBP-230624
deleted in azoospermia-like
IDBP-366815
deleted in azoospermia-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:16586792-16670306
Strand Reverse strand
Band p24.3
Transcripts
ENST00000250863 ENSP00000250863
ENST00000399444 ENSP00000382373
ENST00000454457 ENSP00000398109
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0008494 translation activator activity
GO:0042802 identical protein binding
Biological Process
GO:0001556 oocyte maturation
GO:0007147 female meiosis II
GO:0007275 multicellular organismal development
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0045836 positive regulation of meiosis
GO:0045948 positive regulation of translational initiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005844 polysome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000010592
View Gene Order
ENSBTAG00000000502
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.131179 Hs.613297
RefSeq NM_001190811 NM_001351
HUGO
OMIM
CCDS CCDS43059 CCDS54556
HPRD 09029
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca