Version 5.4
Mus musculus Gene: Rtel1
Summary
InnateDB Gene IDBG-214068.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rtel1
Gene Name regulator of telomere elongation helicase 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000038685
Encoded Proteins
IDBP-214070
regulator of telomere elongation helicase 1
IDBP-214072
regulator of telomere elongation helicase 1
IDBP-214074
regulator of telomere elongation helicase 1
IDBP-263712
regulator of telomere elongation helicase 1
IDBP-263714
regulator of telomere elongation helicase 1
IDBP-531649
regulator of telomere elongation helicase 1
IDBP-535350
regulator of telomere elongation helicase 1
IDBP-533360
regulator of telomere elongation helicase 1
IDBP-540311
regulator of telomere elongation helicase 1
IDBP-531600
regulator of telomere elongation helicase 1
IDBP-790491
regulator of telomere elongation helicase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000258366:
In mice, inactivation of the Rtel (regulator of telomere length) gene has been shown to cause chromosome breaks, fusions, and telomere loss. In addition, Rtel is required for telomere elongation. Therefore, the mouse Rtel gene regulates chromosome stability and telomere length. This gene is the human ortholog of the mouse Rtel gene, so its protein product may play similar roles in humans. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B), generates a non-coding transcript. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:181319739-181356616
Strand Forward strand
Band H4
Transcripts
ENSMUST00000098971 ENSMUSP00000096571
ENSMUST00000054622 ENSMUSP00000053120
ENSMUST00000048608 ENSMUSP00000043563
ENSMUST00000108815 ENSMUSP00000104443
ENSMUST00000108814 ENSMUSP00000104442
ENSMUST00000146273
ENSMUST00000139608
ENSMUST00000153112 ENSMUSP00000118810
ENSMUST00000148252 ENSMUSP00000116159
ENSMUST00000126842
ENSMUST00000125233
ENSMUST00000130935
ENSMUST00000144648
ENSMUST00000130772
ENSMUST00000147266
ENSMUST00000139601
ENSMUST00000124149
ENSMUST00000133856 ENSMUSP00000120162
ENSMUST00000137700 ENSMUSP00000121400
ENSMUST00000134651 ENSMUSP00000123039
ENSMUST00000184751 ENSMUSP00000138971
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0016787 hydrolase activity
GO:0016817 hydrolase activity, acting on acid anhydrides
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000723 telomere maintenance
GO:0006139 nucleobase-containing compound metabolic process
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000258366
View Gene Order
ENSBTAG00000021096
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_196637
Cytosolic iron-sulfur cluster assembly pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160176
Cytosolic iron-sulfur cluster assembly pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.11333 Mm.488418
RefSeq NM_001001882 NM_001166665 NM_001166666 NM_001166667 NM_001166668 XM_006500633 XM_006500636 XM_006500637 XM_006500639 XM_006500640 XM_006500642
OMIM
CCDS CCDS17208 CCDS50849 CCDS50850 CCDS50851 CCDS50852
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca