Version 5.4
Mus musculus Gene: Rgs19
Summary
InnateDB Gene IDBG-214217.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rgs19
Gene Name regulator of G-protein signaling 19
Synonyms 2610042F04Rik; AI324841; AW547781; GAIP
Species Mus musculus
Ensembl Gene ENSMUSG00000002458
Encoded Proteins
IDBP-214219
regulator of G-protein signaling 19
IDBP-263801
regulator of G-protein signaling 19
IDBP-263803
regulator of G-protein signaling 19
IDBP-263805
regulator of G-protein signaling 19
IDBP-263807
regulator of G-protein signaling 19
IDBP-263809
regulator of G-protein signaling 19
IDBP-263811
regulator of G-protein signaling 19
IDBP-541380
regulator of G-protein signaling 19
IDBP-627159
regulator of G-protein signaling 19
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171700:
G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:181688419-181693977
Strand Reverse strand
Band H4
Transcripts
ENSMUST00000002532 ENSMUSP00000002532
ENSMUST00000108779 ENSMUSP00000104409
ENSMUST00000108778 ENSMUSP00000104408
ENSMUST00000108776 ENSMUSP00000104406
ENSMUST00000108772 ENSMUSP00000104403
ENSMUST00000108771 ENSMUSP00000104402
ENSMUST00000108769 ENSMUSP00000104400
ENSMUST00000144476 ENSMUSP00000120723
ENSMUST00000143510
ENSMUST00000124776
ENSMUST00000130712
ENSMUST00000165416 ENSMUSP00000129026
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001965 G-protein alpha-subunit binding
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0016020 membrane
GO:0030136 clathrin-coated vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171700
View Gene Order
ENSBTAG00000021837
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_19333
G alpha (z) signalling events pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_205036
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_205369
Signaling by GPCR pathway
REACT_210568
G alpha (i) signalling events pathway
REACT_214353
Signal Transduction pathway
REACT_209521
G alpha (q) signalling events pathway
REACT_214436
GPCR downstream signaling pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.274366
RefSeq NM_001291205 NM_001291206 NM_001291207 NM_001291210 NM_026446 XM_006500681 XM_006500683 XM_006500685
OMIM
CCDS CCDS17220 CCDS71222 CCDS71223
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca