InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grb2

Summary

InnateDB Gene

IDBG-214339.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grb2

Gene Name

growth factor receptor bound protein 2

Synonyms

AA408164; Ash

Species

Mus musculus

Ensembl Gene

ENSMUSG00000059923

Encoded Proteins

IDBP-214341

growth factor receptor bound protein 2

IDBP-268647

growth factor receptor bound protein 2

IDBP-268649

growth factor receptor bound protein 2

IDBP-268651

growth factor receptor bound protein 2

IDBP-531709

growth factor receptor bound protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177885:
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:115644045-115708597

Strand

Reverse strand

Band

Transcripts

ENSMUST00000021090	ENSMUSP00000021090
ENSMUST00000106499	ENSMUSP00000102108
ENSMUST00000106497	ENSMUSP00000102106
ENSMUST00000106495	ENSMUSP00000102104
ENSMUST00000135065	ENSMUSP00000117539

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 120 experimentally validated interaction(s) in this database.
They are also associated with 605 interaction(s) predicted by orthology.

Experimentally validated
Total	120 [view]
Protein-Protein	120 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	605 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0005070	SH3/SH2 adaptor activity
GO:0005154	epidermal growth factor receptor binding
GO:0005168	neurotrophin TRKA receptor binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0019904	protein domain specific binding
GO:0042802	identical protein binding
GO:0043560	insulin receptor substrate binding
GO:0044822	poly(A) RNA binding
GO:0046875	ephrin receptor binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0007265	Ras protein signal transduction
GO:0007568	aging
GO:0008286	insulin receptor signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0030154	cell differentiation
GO:0030838	positive regulation of actin filament polymerization
GO:0031623	receptor internalization
GO:0042770	signal transduction in response to DNA damage
GO:0043408	regulation of MAPK cascade
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0051291	protein heterooligomerization
GO:0060670	branching involved in labyrinthine layer morphogenesis
GO:0071479	cellular response to ionizing radiation
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0008180	COP9 signalosome
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0070436	Grb2-EGFR complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000177885

View Gene Order

ENSBTAG00000004736

Not yet available

Pathways

NETPATH

REACTOME

REACT_239142

Innate Immune System pathway

REACT_198374

Regulation of actin dynamics for phagocytic cup formation pathway

REACT_203917

EGFR downregulation pathway

REACT_188199

Signaling by the B Cell Receptor (BCR) pathway

REACT_188191

Signaling by ERBB2 pathway

REACT_188194

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway

REACT_223625

GPCR downstream signaling pathway

REACT_205300

PI3K/AKT activation pathway

REACT_189085

Disease pathway

REACT_252337

SHC-related events pathway

REACT_224553

Hemostasis pathway

REACT_199123

Signaling by constitutively active EGFR pathway

REACT_254215

Signaling by GPCR pathway

REACT_240250

Signaling by Insulin receptor pathway

REACT_261365

Interleukin-2 signaling pathway

REACT_227425

Regulation of KIT signaling pathway

REACT_198350

EGFR Transactivation by Gastrin pathway

REACT_188177

Signaling by FGFR in disease pathway

REACT_188579

Signaling by ERBB4 pathway

REACT_188578

Signaling by SCF-KIT pathway

REACT_188573

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_188574

SHC1 events in ERBB2 signaling pathway

REACT_233584

Cytokine Signaling in Immune system pathway

REACT_244029

Signal attenuation pathway

REACT_226341

PIP3 activates AKT signaling pathway

REACT_225233

Cell surface interactions at the vascular wall pathway

REACT_230745

Immune System pathway

REACT_224879

Platelet activation, signaling and aggregation pathway

REACT_239466

SHC-mediated signalling pathway

REACT_230639

Downstream signal transduction pathway

REACT_231729

Downstream signaling of activated FGFR pathway

REACT_198525

Negative regulation of FGFR signaling pathway

REACT_198526

Spry regulation of FGF signaling pathway

REACT_196588

Constitutive PI3K/AKT Signaling in Cancer pathway

REACT_188580

SHC1 events in ERBB4 signaling pathway

REACT_203296

PI3K events in ERBB4 signaling pathway

REACT_223993

PI-3K cascade pathway

REACT_215628

Signal regulatory protein (SIRP) family interactions pathway

REACT_239722

Signalling to RAS pathway

REACT_260286

SHC1 events in EGFR signaling pathway

REACT_242976

Signaling by EGFR pathway

REACT_220092

GPVI-mediated activation cascade pathway

REACT_259732

Insulin receptor signalling cascade pathway

REACT_261451

CD28 dependent Vav1 pathway pathway

REACT_188215

IRS-related events triggered by IGF1R pathway

REACT_188218

IGF1R signaling cascade pathway

REACT_188219

Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway

REACT_204081

CD28 co-stimulation pathway

REACT_210793

Interleukin receptor SHC signaling pathway

REACT_225477

Costimulation by the CD28 family pathway

REACT_213364

Role of LAT2/NTAL/LAB on calcium mobilization pathway

REACT_240139

PI3K Cascade pathway

REACT_261444

Axon guidance pathway

REACT_188204

Fc epsilon receptor (FCERI) signaling pathway

REACT_188202

FCERI mediated Ca+2 mobilization pathway

REACT_231290

Signalling to ERKs pathway

REACT_261687

Signaling by Interleukins pathway

REACT_238268

GRB2:SOS provides linkage to MAPK signaling for Integrins pathway

REACT_226735

PI3K/AKT Signaling in Cancer pathway

REACT_196455

Signaling by FGFR mutants pathway

REACT_196452

Signaling by FGFR1 mutants pathway

REACT_209368

Fcgamma receptor (FCGR) dependent phagocytosis pathway

REACT_248921

Signalling by NGF pathway

REACT_229531

Adaptive Immune System pathway

REACT_263353

Signaling by PDGF pathway

REACT_234357

FRS2-mediated cascade pathway

REACT_188576

Developmental Biology pathway

REACT_94437

SHC-mediated cascade pathway

REACT_241824

SOS-mediated signalling pathway

REACT_206286

GAB1 signalosome pathway

REACT_196460

Signaling by FGFR1 fusion mutants pathway

REACT_243154

IRS-related events pathway

REACT_237883

NGF signalling via TRKA from the plasma membrane pathway

REACT_242206

IRS-mediated signalling pathway

REACT_207835

G-protein beta:gamma signalling pathway

REACT_225836

Interleukin-3, 5 and GM-CSF signaling pathway

REACT_215348

PI3K events in ERBB2 signaling pathway

REACT_188257

Signal Transduction pathway

REACT_188528

GRB2 events in ERBB2 signaling pathway

REACT_211860

Tie2 Signaling pathway

REACT_246176

Integrin alphaIIb beta3 signaling pathway

REACT_223974

G beta:gamma signalling through PI3Kgamma pathway

REACT_242456

Signaling by FGFR pathway

REACT_245103

GRB2 events in EGFR signaling pathway

REACT_249309

Platelet Aggregation (Plug Formation) pathway

REACT_188530

FCERI mediated MAPK activation pathway

REACT_188220

SHC-related events triggered by IGF1R pathway

REACT_223082

Cell-Cell communication pathway

REACT_188180

Signaling by EGFR in Cancer pathway

REACT_237796

NCAM signaling for neurite out-growth pathway

REACT_198634

Regulation of signaling by CBL pathway

REACT_209507

Downstream signaling events of B Cell Receptor (BCR) pathway

REACT_188188

DAP12 interactions pathway

REACT_188185

DAP12 signaling pathway

KEGG

mmu05213

Endometrial cancer pathway

mmu05211

Renal cell carcinoma pathway

mmu04012

ErbB signaling pathway pathway

mmu04630

Jak-STAT signaling pathway pathway

mmu04910

Insulin signaling pathway pathway

mmu05221

Acute myeloid leukemia pathway

mmu04660

T cell receptor signaling pathway pathway

mmu04540

Gap junction pathway

mmu04664

Fc epsilon RI signaling pathway pathway

mmu04650

Natural killer cell mediated cytotoxicity pathway

mmu04912

GnRH signaling pathway pathway

mmu04010

MAPK signaling pathway pathway

mmu05214

Glioma pathway

mmu05215

Prostate cancer pathway

mmu05220

Chronic myeloid leukemia pathway

mmu05223

Non-small cell lung cancer pathway

mmu04510

Focal adhesion pathway

mmu04662

B cell receptor signaling pathway pathway

mmu04062

Chemokine signaling pathway pathway

mmu04722

Neurotrophin signaling pathway pathway

mmu04320

Dorso-ventral axis formation pathway

mmu05200

Pathways in cancer pathway

mmu04380

Osteoclast differentiation pathway

mmu05160

Hepatitis C pathway

INOH