Homo sapiens Gene: ALOX5AP
Summary
InnateDB Gene IDBG-21438.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALOX5AP
Gene Name arachidonate 5-lipoxygenase-activating protein
Synonyms FLAP;
Species Homo sapiens
Ensembl Gene ENSG00000132965
Encoded Proteins
arachidonate 5-lipoxygenase-activating protein
arachidonate 5-lipoxygenase-activating protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:30713478-30764426
Strand Forward strand
Band q12.3
Transcripts
ENST00000380490 ENSP00000369858
ENST00000479597
ENST00000617770 ENSP00000479870
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 4 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004051 arachidonate 5-lipoxygenase activity
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0047485 protein N-terminus binding
GO:0050544 arachidonic acid binding
Biological Process
GO:0002540 leukotriene production involved in inflammatory response
GO:0002675 positive regulation of acute inflammatory response
GO:0006691 leukotriene metabolic process
GO:0019369 arachidonic acid metabolic process
GO:0019370 leukotriene biosynthetic process
GO:0019372 lipoxygenase pathway
GO:0043085 positive regulation of catalytic activity
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0070207 protein homotrimerization
GO:0071277 cellular response to calcium ion
GO:2001300 lipoxin metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Arachidonic acid metabolism pathway
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
Synthesis of Lipoxins (LX) pathway
Metabolism pathway
Synthesis of 5-eicosatetraenoic acids pathway
KEGG
INOH
PID BIOCARTA
Eicosanoid metabolism [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001204406 NM_001629
HUGO
OMIM
CCDS CCDS73558 CCDS9337
HPRD 04742
IMGT
EMBL
GenPept
RNA Seq Atlas